mast cell


Also found in: Thesaurus, Medical, Legal, Financial, Encyclopedia, Wikipedia.

mast cell

n.
A cell produced in bone marrow that functions in allergic reactions and other inflammatory and immune responses by releasing substances such as histamine and cytokines and by directly killing pathogens. Mast cells are found chiefly in connective tissue and contain basophilic granules.

[Partial translation of German Mastzelle, well-fed cell (from an early view that the granules were from phagocytosis) : Mast, food, mast (from Middle High German, from Old High German) + Zelle, cell.]

mast cell

n
(Biology) a type of granular basophil cell in connective tissue that releases heparin, histamine, and serotonin during inflammation and allergic reactions
[C19: from mast2, on the model of German Mastzelle]

mast′ cell`


n.
a large granular cell, common in connective tissue, that produces heparin, histamine, and serotonin.
[1885–90; partial translation of German Mastzelle=Mast mast2 + Zelle cell]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.mast cell - a large connective tissue cell that contains histamine and heparin and serotonin which are released in allergic reactions or in response to injury or inflammation
connective tissue - tissue of mesodermal origin consisting of e.g. collagen fibroblasts and fatty cells; supports organs and fills spaces between them and forms tendons and ligaments
somatic cell, vegetative cell - any of the cells of a plant or animal except the reproductive cells; a cell that does not participate in the production of gametes; "somatic cells are produced from preexisting cells";
References in periodicals archive ?
Mast cell progenitors have been demonstrated in the bone marrow and peripheral blood (7, 8).
The remaining 89 patients included 16 with aggressive systemic disease, 57 with systemic disease and an associated hematologic neoplasm, and 16 with mast cell leukemia.
Referring to the interaction between mast cells and T cells, most investigators focused on mast cell function on T cells.
Conclusion: Mast cell density was seen to have a role in the inflammatory processes of helicobacter pylori infection.
A mast cell is present in different types of tissue and contains many histamine- and heparin-rich granules.
Since then, this condition has evolved to include a number of mast cell activation disorders associated with acute coronary syndrome.
Some bacteria have the ability to stimulate the histamine response independent of IgE mediation--the bacteria themselves or endotoxins seem to trigger basophil, leukocytes and mast cell degranulation.
Cromolyn sodium is considered an antiasthmatic, an anti-allergic and a mast cell stabilizer.
A / Topical antihistamines and topical mast cell stabilizers appear to reduce conjunctival injection and itching effectively.
Anti-mast cell tryptase antibodies allowed us the semi-quantitative evaluation of mast cells within perivascular inflammatory infiltrates noticed in airways mucosa and in superficial dermis.
11) Mast cell activation results in degranulation and the subsequent release of lipid-derived substances and allergy/inflammatory mediators, including histamine, serotonin, and various cytokines and chemokines.
While surgery continues to be the most common treatment for cancerous mast cell tumors (MCTs), advances in veterinary medicine are paving the way for other therapies tailored to individual dogs' needs.