mast cell


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Related to mast cell: Mast cell tumor, mast cell stabilizers, Mast cell disease

mast cell

n.
A cell produced in bone marrow that functions in allergic reactions and other inflammatory and immune responses by releasing substances such as histamine and cytokines and by directly killing pathogens. Mast cells are found chiefly in connective tissue and contain basophilic granules.

[Partial translation of German Mastzelle, well-fed cell (from an early view that the granules were from phagocytosis) : Mast, food, mast (from Middle High German, from Old High German) + Zelle, cell.]

mast cell

n
(Biology) a type of granular basophil cell in connective tissue that releases heparin, histamine, and serotonin during inflammation and allergic reactions
[C19: from mast2, on the model of German Mastzelle]

mast′ cell`


n.
a large granular cell, common in connective tissue, that produces heparin, histamine, and serotonin.
[1885–90; partial translation of German Mastzelle=Mast mast2 + Zelle cell]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.mast cell - a large connective tissue cell that contains histamine and heparin and serotonin which are released in allergic reactions or in response to injury or inflammation
connective tissue - tissue of mesodermal origin consisting of e.g. collagen fibroblasts and fatty cells; supports organs and fills spaces between them and forms tendons and ligaments
somatic cell, vegetative cell - any of the cells of a plant or animal except the reproductive cells; a cell that does not participate in the production of gametes; "somatic cells are produced from preexisting cells";
References in periodicals archive ?
1, 2015 /PRNewswire/ -- Blueprint Medicines (NASDAQ: BPMC), a leader in discovering and developing highly selective kinase medicines for patients with genomically defined diseases, and PatientCrossroads, a pioneer in spearheading the adoption of patient-entered disease registries, today announced the launch of Mast Cell Connect, a patient registry to advance the understanding of mastocytosis and help speed the development of new therapies.
Since then, this condition has evolved to include a number of mast cell activation disorders associated with acute coronary syndrome.
Cromolyn sodium is considered an antiasthmatic, an anti-allergic and a mast cell stabilizer.
This mast cell stabilising effect builds up over a period of a few weeks, so that by the time the allergens are in season, the ocular hay fever symptoms will be greatly reduced.
The aim of this study was to determine whether hydroxytyrosol and oleuropein, the major phenols found in olives and olive oil, inhibit mast cell activation induced by immune and non-immune pathways.
This is understandable, as when the mast cell becomes activated, several other strong mediators besides histamine get released, too.
Bone marrow biopsy 14 days after induction of treatment revealed persistent myeloblasts and mast cell infiltrate requiring a second course of therapy with 5 days of high-dose Ara-C (1 g/[m.
In all three groups of mutant mice, pre-immunization with a low dose of bee venom did not confer protection against a lethal dose, suggesting that the protection depends on IgE signaling and mast cell activation.
Some people may also have a polymorphism of the genes for their IgE receptors on the mast cell, which causes greater than normal responses by mast cells to the binding of IgE.
Mast cells were detected by chloroacetate esterase (CAE) staining according to published protocols of mast cell detection (Beckstead et al.
Recent research conducted by Professor Midoro-Horiuti and colleagues at the University of Texas Medical Branch (UTMB) in Galveston, Texas,' has demonstrated that estradiol can trigger mast cell and basophil activity.