mechanism of action


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mech´an`ism of ac´tion


n.1.(Medicine, Biochemistry) The mechanism{2} by which a pharmacologically active substance produces an effect on a living organism or in a biochemical system; as, the mechanism of action of actinomycin involves its binding to DNA. The mechanism of action is usually considered to include an identification of the specific molecular targets to which a pharmacologically active substance binds or whose biochemical action it influences; a general recognition of the broad biochemical pathways (such as DNA synthesis, protein synthesis, cholesterol synthesis) which are inhibited or affected by a substance is termed its mode of action.
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H1 2014 24 Assessment by Monotherapy Products, H1 2014 25 Assessment by Combination Products, H1 2014 26 Number of Products by Stage and Target, H1 2014 29 Number of Products by Stage and Mechanism of Action, H1 2014 32 Number of Products by Stage and Route of Administration, H1 2014 34 Number of Products by Stage and Molecule Type, H1 2014 36 Nicotine Addiction Therapeutics - Recent Pipeline Updates, H1 2014 54 Nicotine Addiction - Dormant Projects, H1 2014 58 Nicotine Addiction - Discontinued Products, H1 2014 59
This list of genes provided the basis for the final evaluation--testing whether the mechanism of action for ETOP could be accurately classified based upon the genes expressed following exposure.
Although, fortunately, these mutations would be difficult to generate outside the laboratory, they were useful in supporting the novel mechanism of action, since these genetic alterations did not affect the action of other ribosomal drugs.
And in support of the opioid mechanism of action, they found that giving naloxone blocked the analgesic effects of acupuncture.
H1 2014 26 Seizures - Pipeline by Sage Therapeutics, H1 2014 27 Assessment by Monotherapy Products, H1 2014 28 Number of Products by Stage and Target, H1 2014 31 Number of Products by Stage and Mechanism of Action, H1 2014 34 Number of Products by Stage and Route of Administration, H1 2014 36 Number of Products by Stage and Molecule Type, H1 2014 38 Seizures Therapeutics - Recent Pipeline Updates, H1 2014 59 Seizures - Dormant Projects, H1 2014 70 Seizures - Discontinued Products, H1 2014 71
To improve our understanding of the basic biology of brain development, as well as the site and mechanism of action of environmental chemicals that target the thyroid system, we must increase the use of "-omics" technology (e.
This lack of elimination of bactericidal action suggests that these agents possess a secondary bactericidal mechanism of action that does not depend on the synthesis of protein and RNA, and that may be active when the bacteria are in a nonreplicating state (46).
We distil and systematize pipeline, financial, competitive product, mechanism of action, partnering, and patent information to provide the most comprehensive and up-to-date information available.
Scope - The report provides brief overview of JW Pharmaceutical Corporation including business description, key information and facts, and its locations and subsidiaries - The report reviews current pipeline of JW Pharmaceutical Corporation's human therapeutic division and enlists all their major and minor projects - The report features product description and descriptive mechanism of action for key pipeline products along with the product's developmental history and major milestones - Special feature on out-licensed and partnered product portfolio - The report summarizes all the dormant and discontinued pipeline projects - Latest company statement - Latest news and deals relating to the JW Pharmaceutical Corporation's pipeline products
The discovery of XD4241 and the subsequent identification of its mechanism of action validates our systems biology approach to drug discovery and demonstrates how it can rapidly and efficiently identify new drug leads.
The NIEHS Division of Extramural Research and Training (DERT), in collaboration with the National Toxicology Program (NTP), initiated a unique grants program in 1997 that funds investigator-initiated research to provide data to aid in defining the mechanism of action of agents under study by the NTP.
NASDAQ:GENT) today announced that its lead product, Defibrotide, will be highlighted in a presentation made by Professor Ernst Holler in a lecture entitled, "Defibrotide: Mechanism of action and clinical application.