mechanism of action


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mech´an`ism of ac´tion


n.1.(Medicine, Biochemistry) The mechanism{2} by which a pharmacologically active substance produces an effect on a living organism or in a biochemical system; as, the mechanism of action of actinomycin involves its binding to DNA. The mechanism of action is usually considered to include an identification of the specific molecular targets to which a pharmacologically active substance binds or whose biochemical action it influences; a general recognition of the broad biochemical pathways (such as DNA synthesis, protein synthesis, cholesterol synthesis) which are inhibited or affected by a substance is termed its mode of action.
References in periodicals archive ?
This list of genes provided the basis for the final evaluation--testing whether the mechanism of action for ETOP could be accurately classified based upon the genes expressed following exposure.
Although, fortunately, these mutations would be difficult to generate outside the laboratory, they were useful in supporting the novel mechanism of action, since these genetic alterations did not affect the action of other ribosomal drugs.
And in support of the opioid mechanism of action, they found that giving naloxone blocked the analgesic effects of acupuncture.
Galeterone has a novel, combined mechanism of action that hits the receptor in three different ways and may help prevent resistance.
We need more information to understand the site and mechanism of action of these environmental chemicals during brain development.
Bactericidal activity can be achieved through the mechanism of action for a single antimicrobial agent or by the use of combination therapy, or both.
NASDAQ:GENT) today announced that its lead product, Defibrotide, will be highlighted in a presentation made by Professor Ernst Holler in a lecture entitled, "Defibrotide: Mechanism of action and clinical application.
This report provides comprehensive information on the therapeutic development for Methicillin-Susceptible Staphylococcus Aureus (MSSA) Infections, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases.
This report provides comprehensive information on the therapeutic development for Insomnia, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases.
Xcellsyz Ltd, Newcastle, UK, a company focused on the discovery of new drugs for diabetes and obesity through the use of novel cell-based technologies, has identified the mechanism of action of its lead antidiabetic compound XD4241.