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v. me·di·at·ed, me·di·at·ing, me·di·ates
1. To resolve or settle (differences) by working with all the conflicting parties: mediate a labor-management dispute.
2. To bring about (a settlement, for example) by working with all the conflicting parties.
a. To effect or convey as an intermediate agent or mechanism: chemicals that mediate inflammation.
b. Physics To convey (a force) between subatomic particles.
1. To work with two or more disputants in order to bring about an agreement, settlement, or compromise.
2. To settle or reconcile differences: "[George] Eliot's effort to mediate between the conflicting demands of representation and readability in the [novel's] dialect usage" (Carol A. Martin).
3. To have a relation to two differing persons, groups, or things: psychological processes that mediate between stimulus and response.
adj. (-ĭt)
1. Acting through, involving, or dependent on an intervening agency.
2. Being in a middle position.

[Late Latin mediāre, mediāt-, to be in the middle, from Latin medius, middle; see medhyo- in Indo-European roots.]

me′di·ate·ly (-ĭt-lē) adv.
me′di·a′tion (-ā′shən) n.
me′di·a′tive, me′di·a·to′ry (mē′dē-ə-tôr′ē) adj.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Adj.1.mediated - acting or brought about through an intervening agencymediated - acting or brought about through an intervening agency; "the mediated settlement brought satisfaction to both sides"
mediate - acting through or dependent on an intervening agency; "the disease spread by mediate as well as direct contact"
References in periodicals archive ?
While there is ample evidence from model systems that small RNAs are the lynchpin of powerful mechanisms that silence transcription, the demonstration of transcriptional gene silencing (TGS) mediated by a small RNA in humans is lacking.
The Mediated Construction of Political Scandals in Four Nordic Countries
Reproductive effects of ethylene glycol mono-methyl ether may be mediated by its primary metabolite, methoxyacetic acid (MAA), a short-chain fatty acid that inhibits histone deacetylase activity and alters gene expression.
Talks between Syria and Israel were previously mediated by Turkey.
Handbook of research on computer mediated communication; 2v.
Maniv Energy Capital (Hasbrouck, NJ) has patented a method of modulating an Edg-3 receptor mediated biological activity in a cell.
This study investigates the students' perceptions of problem-based online learning in regard to computer mediated communication, benefits for learning, online support, motivation, and online collaboration.
Using electronic mail surveys and computer Monitored data for studying computer mediated communication systems.
3) Cohen's interpretation locates civil society--defined as "the dense network of voluntary, and especially philanthropic, organizations that mediated between the individual and the state"--not at the periphery but rather at the very center of stability traditionally understood as shaped by states and special interest groups.
These ionic changes are mediated by the specific chemokine co-receptor, rather than the CD4 receptor, as shown by experiments using CXCR4 antagonists and CCR5-deficient macrophages.
Methotrexate in the management of immune mediated cochleovestibular disorders: Clinical experience with 53 patients.
This finding bolsters the theory that endothelial dysfunction associated with preeclampsia is mediated by oxidative stress because ascorbic acid is a powerful antioxidant that scavenges oxygen-derived free radicals.