1,2) The most common cause of this phenomenon is megaloblastic
anemia due to folate and/ or vitamin B12 deficiency.
Left untreated, it causes vitamin B12 deficiency, which leads to megaloblastic
anemia (characterized by a lower-than-normal red blood cell count) and neurological disorders-which are sometimes irreversible.
0%) patients and normoblastic with mild megaloblastic
changes in 4 (7.
anemia are a group of disorders characterized by the presence of distinctive morphologic appearances of the developing red cells in bone marrow.
It is a striking feature of many serious and life-threatening illnesses, ranging from simple drug-induced bone marrow hypoplasia, megaloblastic
anemia to fatal bone marrow aplasias and leukemias.
Macrocytosis with associated anaemia could be due to megaloblastic
causes, based on bone marrow examination findings.
Septic shock (Septic shock is a life-threatening condition that happens when your blood pressure drops to a dangerously low level after an infection), failure of erythropoiesis (lack of production of red blood cells), haemorrhage, dilutional anaemia following severe burns and megaloblastic
anaemia(a blood disorder in which the number of red blood cells is lower than normal), gastrointestinal haemorrhage, bone marrow transplant.
2 Nutritional megaloblastic
anemia occurs commonly among under-nourished societies of tropical and subtropical countries and incidence has dramatically increased over pastdecades.
changes especially in the myeloid series, plasma cell, marked increase in the number of hystiocytes and a high number of hemofagocytes were observed on bone marrow aspiration biopsy which was performed on the second day of hospitalization because of bicytopenia.
Peripheral Vascular Disease, DVT and Pulmonary Embolism, Hepato Cellular Carcinoma, DCLD, Abdominal tuberculosis, Inflammatory Bowel Disease, Malabsorption, Acute Hepatitis, Enteric Fever, Pulmonary tuberculosis, Leptospirosis, Leukemia, Lymphoma, Myelopoliferative Disorders, Hemophilia, Aplastic Anemia, Hemolytic Anemia, Megaloblastic
Anemia, Iron Deficiency Anaemia, Acute Kidney Injury, Chronic Renal Failure, Glumeronephritis, Cushing's Syndrome and Diabetes Mellitus.
12,14] Also, since the CHr is calculated from the reticulocyte MCV, patients with haemoglobinopathy associated with microcytosis will have a falsely low CHr, while patients with megaloblastic
anaemia or macrocytic indices (MCV >100 fl), including some patients on antiretroviral therapy, will have a falsely elevated CHr.
Other associated complications of GT are malabsorption related, which include protein-losing enteropathy, iron deficiency anemia, and megaloblastic