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An abnormally large immature red blood cell (erythroblast) found especially in the blood of people with certain types of anemia and often associated with vitamin B12 deficiency.

meg′a·lo·blas′tic adj.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Adj.1.megaloblastic - of or relating to megaloblastsmegaloblastic - of or relating to megaloblasts  
References in periodicals archive ?
Our study showed that peak incidence of Megaloblastic anemia in middle age group (41 to 50 years) with an equal sex ratio which is supported by studies.
This kind of anaemia, megaloblastic, can be very severe and it may also affect the nerves in the hands and the feet which can tingle and even go numb.
Although his declared interest was haematology, characterised by seminal publications on iron deficiency, megaloblastic and protein deficiency, he was equally at home exercising his clinical acumen and even co-authoring.
Megaloblastic anemia is characterized by megaloblastic erythropoiesis and is secondary to decreased activity of methionine synthase, one of two mammalian enzymes that requires vitamin B12 (cobalamin) as a cofactor.
A peripheral smear can detect megaloblastic changes typical of [B.
12] therapy, in a pilot study of patients with severe megaloblastic anemia attributable to vitamin [B.
A bone marrow biopsy revealed a hypercellular marrow with hyperplastic megaloblastic erythropoiesis and leukopenia.
1,2) The most common cause of this phenomenon is megaloblastic anemia due to folate and/ or vitamin B12 deficiency.
Left untreated, it causes vitamin B12 deficiency, which leads to megaloblastic anemia (characterized by a lower-than-normal red blood cell count) and neurological disorders-which are sometimes irreversible.
0%) patients and normoblastic with mild megaloblastic changes in 4 (7.
The megaloblastic anemia are a group of disorders characterized by the presence of distinctive morphologic appearances of the developing red cells in bone marrow.
It is a striking feature of many serious and life-threatening illnesses, ranging from simple drug-induced bone marrow hypoplasia, megaloblastic anemia to fatal bone marrow aplasias and leukemias.