megaloblastic anaemia


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megaloblastic anaemia

n
(Pathology) any anaemia, esp pernicious anaemia, characterized by the presence of megaloblasts in the blood or bone marrow
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.megaloblastic anaemia - anemia characterized by many large immature and dysfunctional red blood cells (megaloblasts) in the bone marrowmegaloblastic anaemia - anemia characterized by many large immature and dysfunctional red blood cells (megaloblasts) in the bone marrow; associated with pernicious anemia
malignant anaemia, malignant anemia, pernicious anaemia, pernicious anemia - a chronic progressive anemia of older adults; thought to result from a lack of intrinsic factor (a substance secreted by the stomach that is responsible for the absorption of vitamin B12)
References in periodicals archive ?
Hypersegmentation of neutrophils are mainly seen due to megaloblastic anaemia, where there is deficiency of vitamin B12 and folic acid.
Megaloblastic anaemia in Chinese patients: a review of 52 cases.
12,14] Also, since the CHr is calculated from the reticulocyte MCV, patients with haemoglobinopathy associated with microcytosis will have a falsely low CHr, while patients with megaloblastic anaemia or macrocytic indices (MCV >100 fl), including some patients on antiretroviral therapy, will have a falsely elevated CHr.
12 Depending on extent of deficiency, clinical manifestations can range from impaired memory, dementia, delirium, peripheral neuropathy, sub acute combined degeneration of the spinal cord, megaloblastic anaemia and pancytopenia.
12] deficiency was first reported in six South Indian infants, who presented at 7-12 months with megaloblastic anaemia, developmental regression and skin hyperpigmentation.
Megaloblastic anaemia due to vitamin B12 deficiency was diagnosed through a combination of clinical and laboratory findings, including clinical presentation, increased mean corpuscular volume (macrocytosis), hypersegmentation of neutrophils, and low vitamin B12 levels.
Key features distinguishing the main differential diagnoses of VACTERL association Syndrome Features distinct from VA Fanconi anaemia Haematologic abnormalities, especially megaloblastic anaemia Pigmentation abnormalities, especially hyperpigmentation or Cafe au lait spots Propensity to develop malignancies Alagile syndrome Biliary duct abnormality Eye anomalies Facial abnormality Charge syndrome Choanal atresia Colobomata Growth impairment Ear anomalies Feingold syndrome Digital phalangeal abnormalities Microcepahly Cognitive impairment Typical facial appearance Oculo-auriculo- Microtia vertebral syndrome Hemifacial microsomia Neurocognitive impairment Deletion 22q11.
Investigation of the cause of megaloblastic anaemia was beyond the scope of this study.
Megaloblastic anaemia is a type of anaemia caused by lack of vitamin B12 or folic acid.
12] deficiency which is likely to result in megaloblastic anaemia, further affecting haemoglobin levels [11].
Pernicious anaemia is an inability for the body to absorb sufficient vitamin B12 into the body from the gastro-intestinal tract and accounts for 80% of all megaloblastic anaemia.
In these cases, the commonest symptoms are nonspecific abdominal pain, nausea, vomiting, and iron deficiency or megaloblastic anaemia.