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megaloblastic anemia

   Also found in: Medical, Acronyms, Encyclopedia, Wikipedia 0.02 sec.
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Noun1.megaloblastic anemia - anemia characterized by many large immature and dysfunctional red blood cells (megaloblasts) in the bone marrowmegaloblastic anemia - anemia characterized by many large immature and dysfunctional red blood cells (megaloblasts) in the bone marrow; associated with pernicious anemia
malignant anaemia, malignant anemia, pernicious anaemia, pernicious anemia - a chronic progressive anemia of older adults; thought to result from a lack of intrinsic factor (a substance secreted by the stomach that is responsible for the absorption of vitamin B12)


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In reviewing the patient's chart, you quickly noticed the anemic blood values for hemoglobin and hematocrit, but you also noticed the red blood cell indices (MCV and MCH) suggested not the typical iron deficiency anemia (microcytosis), but a megaloblastic anemia.
Megaloblastic anemia and non-megaloblastic macrocytic anemia together form a group, called macrocytic anemia.
The cause of megaloblastic anemia is primarily a failure of DNA synthesis with preserved RNA synthesis, which result in restricted cell division of the progenitor cells.
 
 
 
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