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melanoblast

   Also found in: Medical, Encyclopedia 0.01 sec.
mel·a·no·blast  (ml-n-blst, m-ln-)
n.
A precursor cell of a melanocyte or melanophore.

mela·no·blastic adj.
ThesaurusLegend:  Synonyms Related Words Antonyms
Noun1.melanoblast - an epidermal cell that is a precursor of a melanocyte
epidermal cell - any of the cells making up the epidermis


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It has been postulated that during early embryogenesis, melanoblasts migrate from the neural crest to various sites, including the epidermis, hair follicles, oral cavity, uvea, leptomeninges, and inner ear, which accounts for the development of primary malignant melanoma in these sites.
Coverage begins with physiology--historical and comparative perspectives, followed by contributions on the science of pigmentation, including general biology of mammalian pigmentation, extracutaneous melanocytes, regulation of melanoblast migration and differentiation, the chemistry and physical properties of melanins, aging and senescence of melanocytes, the genetics of melanoma, and the transformed phenotype of melanocytes, among other topics.
4,42) The role of the c-kit proto-oncogene that encodes the transmembrane tyrosine kinase receptor KIT/SCF-R is unclear, despite the KIT receptor involvement in melanoblast migration and differentiation toward melanocytes.
 
 
 
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