POTENTIALLY LIFE-THREATENING DRUG COMBINATIONS DRUG NAME CONDITION TREATED Isosorbide dinitrate heart disease Itraconazole fungal infections Selegiline Parkinson's disease Tamsulosin enlarged prostate sildenafil hypertension simvastatin high cholesterol meperidine
pain sildenafil erectile dysfunction
Pain medications, such as codeine or meperidine
We evaluated claims for 11 Schedule II opioid analgesics--codeine phosphate, codeine sulfate, hydromorphone, levorphanol, meperidine
-promethazine combination, methadone, morphine, oxycodone--acetaminophen combination, oxycodone-aspirin combination, and controlled-release oxycodone.
Opioid painkillers other than methadone were morphine, codeine, oxycodone, hydrocodone, meperidine
, propoxyphene, hydromorphone, fentanyl, pentazocine, and tramadol.
He was allergic to penicillin, thiopental sodium, and meperidine
Clonidine was effective in all 20 patients, meperidine
was effective in 18 of 20 patients with the remaining two patients requiring a second dose, and urapidil was effective in 6 patients after the first dose and in another 6 after the second dose.
The increase in use was most evident among prescription analgesics, which include codeine, methadone, meperidine
(Demerol), Percocet, hydrocodone (Vicodin), and oxycodone (OxyContin).
The company has been given approval for meperidine
hydrochloride, a generic form of Demerol (Sanofi-Synthelabo Inc.
Most of the anesthesia literature reviewed discussed the use of a combination of morphine and midazolam intramuscularly (IM) or intravenously (IV) for management of patients undergoing cardiac catheterization (Roy, 1997) and meperidine
or pentobarbital IM or IV for procedures greater than 30 minutes in duration (Cote, 1994).
33 12/8/97 4:45:00 PM 86 23 130 46 74 12/8/97 4:48:00 PM 87 16 130 40 70 12/8/97 4:50:00 PM 85 18 137 47 77 12/8/97 4:55:00 PM 86 18 140 44 76 VITALS D/T Medication Route 12/8/97 3:37:00 PM Meperidine
As for resulting mortality among patients 50 years or older, the frequently-prescribed narcotic meperidine
hydrochloride (Demerol) was mentioned in only eight medical examiner reports -- indeed, less than one-fourth the number of aspirin-related reports.
In addition, the company now offers drug screening tests for heroin metabolite 6-Monoacetylmorphine, alcohol biomarkers ethyl glucuronide (EtG) and ethyl sulfate (EtS), and meperidine