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1. Normal transformation of tissue from one type to another, as in the ossification of cartilage to form bone.
2. Transformation of cells from a normal to an abnormal state.

met′a·plas′tic (-plăs′tĭk) adj.

met·a·plasm 1

Alteration of a word by the addition, omission, or transposition of sounds or syllables or the letters that represent them.

[Middle English metaplasmus, from Latin, from Greek metaplasmos, remodeling, from metaplassein, to remold : meta-, meta- + plassein, to mold; see pelə- in Indo-European roots.]

met′a·plas′tic (-plăs′tĭk), met′a·plas′mic (-plăz′mĭk) adj.

met·a·plasm 2

Cellular materials such as pigment granules or starch grains that were formerly considered to be nonliving, in contrast to the protoplasm.

met′a·plas′mic (-plăz′mĭk) adj.


(Biology) relating to, produced by, or characterized by metaplasia
References in periodicals archive ?
This may result from a malignant infiltrative process, hypercalcemia secondary to a paraneoplastic syndrome, end stage renal disease, calcium-phosphate abnormalities caused by hyperparathyroidism or other metabolic derangements, or from a local metaplastic process resulting from repeated trauma or a chronic inflammatory state.
In addition, Helicobacter pylon organisms may be identified in the metaplastic foci, and rarely pancreatic and osseous metaplasia may be identified.
3) These features seen in osteoma are challenging to differentiate from other diseases of bone, including ossifying fibroma, fibrous dysplasia, and metaplastic ossification.
In addition, malignant metamorphosis in areas of leukoplakia, hyperplastic and metaplastic changes due to chronic irritation, and exposure to carcinogenic agents are possible causes of ureteral stump tumors.
Metaplastic bone formation in the subcutaneous nodule of a patient with mixed connective tissue disease.
The predominant one, the metaplastic theory, postulates that there is a common ancestor cell, and through metaplasia of the original squamous cell carcinoma, the sarcomatous component arises.
Clinicians who suspect this is the cause of a patient's discomfort will need to differentiate it from acquired distichiasis, which is metaplastic eyelash growth that results from chronic lid inflammation.
In its most serious form, affecting about 10% of gastroesophageal reflux disease (GERD) patients, the constant reflux of acid can cause Barrett's esophagus, a metaplastic change of the esophageal lining that is associated with the development of esophageal cancer.
In contrast to those not exposed to DEE, those who were had clear goblet cell hyperplasia with increased metaplastic and dysplastic epithelia and an increase in leukocytes.
Still, about 50% of patients not only completely eliminate dysplasia, but actually replace the intestinal metaplastic cells with normal esophageal squamous mucosa.
Utilizes a high-resolution display and proprietary software to provide an image that can be reviewed by a physician to identify areas of suspicion such as inflammatory, metaplastic or dysplastic changes, or possible cancers.