It occurred to me that steady state distribution is equivalent to the metastatic tumor
distribution that shows up in the autopsy datasets," Newton explained.
TTF-1 Diagnosis 1 - Metastatic tumor
2 + Primary lung 3 - Metastatic tumor
4 ([dagger]) + Metastatic tumor
5 - Metastatic tumor
6 + Primary lung 7 [+ or -] Primary lung ([double dagger]) 8 - Metastatic tumor
9 + Primary lung 10 + Primary lung 11 - Metastatic tumor
12 - Metastatic tumor
13 + Primary lung 14 - Metastatic tumor
15 - Metastatic tumor
16 + Primary lung 17 - Metastatic tumor
18 + Primary lung 19 - Metastatic tumor 20 - Metastatic tumor 21 - Metastatic tumor 22 - Metastatic tumor 23 - Metastatic tumor 24 - Metastatic tumor 25 - Metastatic tumor 26 - Metastatic tumor 27 - Metastatic tumor from large bowel 28 - Metastatic tumor 29 - Metastatic tumor 30 + Primary lung 31 ([parallel]) - Metastatic tumor 32 ([parallel]) - Metastatic tumor 33 ([parallel]) - Metastatic tumor Case No.
Depending on the patient's age and the location of the tumor, the differential diagnosis includes malignant schwannoma, malignant fibrous histiocytoma, fibrosarcoma, amelanotic melanoma, malignant lymphoma, squamous cell carcinoma, extramedullary plasmacytoma, metastatic tumor
, glandular tumor, chondroma, chondrosarcoma, osteogenic sarcoma, and inverted papilloma.
Nineteen of nineteen lymph nodes were involved with metastatic tumor
and there were additional mesenteric deposits.
The researchers report that nine of the treated individuals improved; five experienced a complete remission of their major metastatic tumor
The most common metastatic tumor
was adenocarcinoma 24 (52.
Our work provides evidence that innate immunity plays a major role in protecting tissues against metastatic tumor
growth," said study researcher Ivan Stamenkovic, director of the Department of Experimental Pathology at the University of Lausanne in Switzerland.
In each of the six patients, expression was greater in the metastatic tumor
than in the primary tumor.
In the lymph node, the architecture was largely replaced with metastatic tumor
composed of islands of pleomorphic cells, with eosinophilic cytoplasm suggestive of urothelial origin.
In turn, these continuously recruited monocytes and the resultant macrophages promote the growth of the emerging metastatic tumor
Therefore, we suggest that breast carcinomas in patients with prostatic adenocarcinoma should be carefully evaluated using immunostains to clearly distinguish primary from metastatic tumor
when the distinction is not clearly evident on the basis of routine hematoxylin-eosin-stained sections and clinical data.
As a result, immunohistochemical staining of metastatic tumor
of the lymph node may help in determining the origin of the primary tumor.