methapyrilene


Also found in: Thesaurus, Medical, Wikipedia.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.methapyrilene - antihistamine used to treat allergic responses (as rhinitis or dermatitis or pruritus)
antihistamine - a medicine used to treat allergies and hypersensitive reactions and colds; works by counteracting the effects of histamine on a receptor site
Mentioned in ?
References in periodicals archive ?
METHODS: Male rats were given the hepatotoxicant methapyrilene at two dose levels, with livers and kidneys removed 24 hr after one, three, and seven doses for gene expression analysis.
It is methapyrilene and was sold under the trade names Co-Pyronil and Histadyl EC.
That has only happened three times in the past 25 years: in 1977 with the antimicrobial hexachlorophene, in 1979 with the antihistamine methapyrilene and in 1978 with the laxative danthron.
2004) and of rat hepatic gene expression changes induced by methapyrilene (Waring et al.
That happened in 1977 with the antimicrobial hexachlorophene, two years later with the antihistamine methapyrilene and again in 1987 with danthron, a laxative.
We evaluated gene expression patterns from cultured rat primary hepatocytes after a 24-hr incubation with methapyrilene (MP).
Statistical analyses of a methapyrilene study vividly demonstrate sources of "false discoveries" (Chapter 6).
These results are consistent with those of a previously reported study where methapyrilene toxicity correlated with the severity of pathologic changes (Hamadeh et al.
Interlaboratory evaluation of rat hepatic gone expression changes induced by methapyrilene.
Toward this goal, the Hepatotoxicity Working Group of the International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute (HESI) Technical Committee on Application of Genomics to Mechanism-Based Risk Assessment evaluated and compared biological and gene expression responses in rats exposed to two model hepatotoxins--clofibrate and methapyrilene.
To address this question, several members of the Hepatotoxicity Working Group of the International Life Sciences Institute Health and Environmental Sciences Institute evaluated the liver gene expression profiles of rats treated with methapyrilene (MP).
The Hepatotoxicity Working Group of the International Life Sciences Institute Health and Environmental Sciences Institute consortium on the application of genomics to mechanism-based risk assessment is investigating these factors by comparing high-density gene expression data sets generated on two sets of RNA from methapyrilene (MP) experiments conducted at Abbott Laboratories and Boehringer-Ingdheim Pharmaceuticals, Inc.