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Related to methicillin: oxacillin, vancomycin


A semisynthetic penicillin, C17H20N2O6S, formerly used in the form of its sodium salt to treat infections caused by penicillinase-producing staphylococci.

[Blend of methoxy- (meth- + oxy-) and penicillin.]


(Pharmacology) a semisynthetic penicillin used to treat various infections
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Noun1.methicillin - antibiotic drug of the penicillin family used in the treatment of certain staphylococcal infectionsmethicillin - antibiotic drug of the penicillin family used in the treatment of certain staphylococcal infections
penicillin - any of various antibiotics obtained from Penicillium molds (or produced synthetically) and used in the treatment of various infections and diseases


n meticilina
References in periodicals archive ?
To the Editor: A new methicillin resistance mechanism gene, a divergent mecA homologue named mecC (formerly mecALGA251), was recently described in Staphylococcus aureus (1).
aureus infections relies on the production of virulence factors and the pathogenic attitude is frequently enhanced by acquisition of resistance to antimicrobials [3] such as the resistance to methicillin.
The frequency of methicillin resistance in CoNS is notably high and it has been suggested that this may provide a reservoir to propagate methicillin resistance into other Staphylococcus species (Lindsay & Holden, 2004).
Finally, we found that methicillin resistance was community acquired in 1 of the 2 patients with MRSA in the first study group and in 23 of the 26 in the second.
aureus first developed resistance to penicillin in the 1940s, and then to methicillin in early 1960s.
Community-acquired MRSA isolates possess novel methicillin resistance genetic cassettes (especially the staphylococcal cassette chromosome mec type IV), and are associated with a phage that encodes for the virulence factor, PantonValentine leukocidin (PVL) toxin, which is postulated to be at least partly responsible for the increased virulence of CA-MRSA compared to HA-MRSA (Boyle-Vavra S & Daum, 2007; Monecke et al, 2006; Soderquist et al, 2006).
This led to the discovery and use of other antimicrobials such as methicillin in the 1960s.
Resistance of isolates to methicillin was measured using the disc diffusion method.
Staphylococcal chromosome cassette mec type IV (SCCmecIV) that encodes for methicillin resistance and certain genes that encode for multiple virulence factors, such as the Panton-Valentine leucocidin and enterotoxins a, c, and k, are mainly encountered with community-associated MRSA.
SAN FRANCISCO -- Methicillin resistance was noted in 69% of community-acquired soft tissue infections due to Staphylococcus aureus in a single-center study of hospitalized adults in Detroit.
Sixty-one (77%) of those infections were methicillin resistant (5).
Now a study in the British Medical Journal looked at cases of methicillin resistant Staphylococcus aureus (MRSA) and methicillin sensitive Staphylococcus aureus (MSSA) bacteraemia in patients arriving at two Oxfordshire hospitals between 1997 and 2003.

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