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A folate antagonist, C20H22N8O5, that inhibits DNA synthesis and is used to treat psoriasis, certain cancers, and some inflammatory diseases such as rheumatoid arthritis. It is sometimes used in combination with misoprostol to induce abortion in early pregnancy.

[methotre- (probably shortening and alteration of methylaminopterin, one of its chemical names : methyl + aminopterin) + perhaps (o)x(y)- + -ate.]


(ˌmɛθəʊˈtrɛkseɪt; ˌmiːθəʊ-)
(Pharmacology) an antimetabolite drug used in the treatment of certain cancers. Formula: C20H22N8O5


(ˌmɛθ oʊˈtrɛk seɪt)

a toxic folic acid analogue, C20H22N8O5, that inhibits cellular reproduction and is used in the treatment of psoriasis and certain cancers.
[1950–55; metho (xy)- + trexate, of unclear derivation]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.methotrexate - toxic antimetabolite that limits cellular reproduction by acting as an antagonist to folic acid; used to treat certain cancers and psoriasis and rheumatoid arthritis
antimetabolite - an antineoplastic drug that inhibits the utilization of a metabolite


n metotrexato, metotrexate m
References in periodicals archive ?
The first evidence to establish that in vivo involvement of adenosine receptors in the mechanism of action of methotrexate is from the same murine air pouch model.
Both baricitinib regimens were superior to methotrexate monotherapy in inducing clinical remission, using measures such as SDAI, at weeks 24 and 52
Currently, Amgen is in the process of starting a trial in which the goal is to enroll 840 subjects with early PsA who are being randomized to methotrexate alone, Enbrel alone, or Enbrel plus methotrexate.
Methotrexate works by blocking the action of a key enzyme, dihydrofolate reductase (DHFR), which cancer cells require to thrive.
Our clinical message is that methotrexate is overused.
The use of methotrexate for the medical treatment of ectopic pregnancies was first described in 1982.
Medac President and CEO Terri Shoemaker stated, sanctioning announced a big day for patients who will benefit from the therapy, Methotrexate has long been recognized as a mainstay in RA therapy, she said.
Scientists have revealed that if the herbal medicine, which is used to relieve joint pain and inflammation, is combined with methotrexate then the treatment can be all the more effective.
When I was given methotrexate, the medical staff explained everything to me, which helped to put my mind at ease.
Methotrexate is a drug that has seen wide applications in the treatment of malignant diseases.
10]-methylpteroic acid, a minor (<5%) endogenous methotrexate metabolite and the major (>98%) product of pharmacologic inactivation of methotrexate with car-boxypeptidase [G.
He was diagnosed with psoriatic arthritis in 2006, for which he had used methotrexate 10 mg per week for the past three years.