Background: DNA methylation
has been suggested as a biomarker for early cancer detection and treatment.
The function of genome methylation
in invertebrates has only recently been characterized in-depth.
sensitive amplified polymorphism (MSAP) was used to induce DNA methylation
transformation in mushroom mycelia.
2012) reported that maternal smoking during pregnancy was associated with differential DNA methylation
in newborns at specific loci that replicated in a second population.
001506) Circulation: Cardiovascular Genetics found that smoking leaves its "footprint" on the genome through DNA methylation
, the process by which cells control gene expression.
at CpG dinucleotides is a well-studied epigenetic mechanism, defined as a heritable and enzyme-induced chemical modification of DNA, not altering the DNA sequence (Wu et al.
In a paper published June 20 in the Proceedings of the National Academy of Sciences, scientists examined how a process known as methylation
, which can reduce the expression of specific genes, affects a gene called OXT.
They also found evidence that this methylation
signature may be present in many more types of cancer.
Part of the solution lies in using DNA methylation
as a biomarker for differentiation capacity.
It is known that epigenetic DNA methylation
regulates gene expression and is sensitive to the redox environment [5, 11, 12].
of DNA occurs on cytosines and can be transmitted over many cell generations to sustain epigenetic memory.
7) In addition to differential methylation
of the host genome, there is evidence of changes to other epigenetic mechanisms in HPV-positive OPSCCs.