The novel hydrophilic (non oil-based) formulation of minocycline
may be more effective than other topical alternatives because they either use less effective antibiotics to penetrate the top layer of skin or rely on higher concentrations of minocycline
, which could lead to unpleasant side effects.
Patients were randomized into three equal groups of 50 patients, who received placebo, or one of two Minocycline
Foams - 1% or 4%.
Another combination that may work is minocycline
extended release (Solodyn) about 1 mg/kg daily, daily clindamycin phosphate 1.
The randomized double blind Phase II clinical study, conducted in pediatric patients with impetigo, was designed to assess the efficacy, safety and tolerability of two strengths of the Minocycline
Half the patients will take minocycline
with their standard anti-psychotic treatment, the other half will take a placebo.
Owing to its relatively small size (495 Da) and highly lipophilic nature, minocycline
crosses the blood-brain barrier (BBB) with ease and has been shown to penetrate the cerebrospinal fluid (CSF) of human beings better than doxycycline and other tetracyclines (6,7).
6 million prescriptions were written by dermatologists for minocycline
, doxycycline and/or tetracycline, totaling over $1.
Hydrochloride extended release tablet (Minocycline
ER) is reportedly the generic version of Solodyn ER, a treatment for acne, sold by Medicis Pharmaceuticals.
Filipovic and Zecevic studied whether minocycline
would protect human nerve cells grown in lab dishes.
Tissue was collected from the lumbar enlargement (L4 spinal segment) of animals from the following groups: intact (n = 3), SCI + vehicle (n = 12), or SCI + minocycline
(n = 12).
Warminster, Pa, USA) is an approved local delivery system featuring lmg of minocycline
hydrochloride microencapsulated in resorbable polymer microspheres (polyglycolide- A co-dl-lactide).
treatment in this study did not correlate with a lower risk of death, myocardial infarction, recurrent strokes, or hemorrhagic transformation.