monoclonal antibody


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monoclonal antibody

n.
Any of the highly specific antibodies produced in large quantity by the clones of a single hybridoma cell.

monoclonal antibody

(ˌmɒnəʊˈkləʊnəl)
n
(Biochemistry) an antibody, produced by a single clone of cells grown in culture, that is both pure and specific and is capable of proliferating indefinitely to produce unlimited quantities of identical antibodies: used in diagnosis, therapy, and biotechnology

mon′oclo′nal an′tibody



n.
any antibody produced by a laboratory-grown cell clone, either of a hybridoma or a virus-transformed lymphocyte, in order to achieve greater abundance and uniformity than provided by a natural antibody. Abbr. MAb
[1970–75]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.monoclonal antibody - any of a class of antibodies produced in the laboratory by a single clone of cells or a cell line and consisting of identical antibody molecules
antibody - any of a large variety of proteins normally present in the body or produced in response to an antigen which it neutralizes, thus producing an immune response
infliximab, Remicade - a monoclonal antibody (trade name Remicade) used to treat Crohn's disease and rheumatoid arthritis; administered by infusion; use and dosage must be determined by a physician
Translations
References in periodicals archive ?
A monoclonal antibody is a particle that latches on to a specified protein, for example, a receptor on the surface of certain immune cells.
It has also signed an agreement with a leading US monoclonal antibody technology company to conduct feasibility studies for the development of a monoclonal antibody.
The Cancer Monoclonal Antibody Partnering Agreements report provides an understanding and access to the cancer monoclonal antibody partnering deals and agreements entered into by the worlds leading healthcare companies.
Together with our own capabilities for genomics-based therapeutic protein discovery, we expect this alliance to rapidly yield a number of promising new monoclonal antibody candidates.
The anti-CD3 monoclonal antibody homes in on the CD3 molecule, which sits in the membrane of immune-system cells called T-cells and serves as a docking site that helps these cells recognize their targets.
Our report covers the analysis of the entire monoclonal antibody market for cancer, and presents market forecasts for leading products.
Antibody medicine is generally obtained from monoclonal antibody through genetic engineering, possessing the advantages of strong targeting and few drug side effects.
The newly approved monoclonal antibody, caled OKT3, attacks T cells, a subset of which can cause acute rejection of the kidney.
This results from an improved glycosylation profile that increases interaction with effector cells after the monoclonal antibody binds to a target cell.
All 10 mice given the human monoclonal antibody survived a high dose of bacterium.
This report explains what monoclonal antibodies are, and why large pharmaceutical companies are investing so heavily both in developing such drugs internally and acquiring monoclonal antibody candidates from others.
While Seaman expects that the T cell dependence also holds for humans, he doesn't think monoclonal antibody therapy is ready for use.

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