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Related to monogenic: monogenic disease


1. Of or regulated by one gene or one of a pair of allelic genes.
a. Of or relating to monogenesis; monogenetic.
b. Of or relating to monogenism.

mon′o·gen′i·cal·ly adv.


1. (Genetics) genetics of or relating to an inherited character difference that is controlled by a single gene
2. (Biology) (of animals) producing offspring of one sex


(ˌmɒn əˈdʒɛn ɪk)

1. bearing only male or only female forms.
2. pertaining to or being controlled by a single gene.
mon`o•gen′i•cal•ly, adv.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Adj.1.monogenic - of or relating to an inheritable character that is controlled by a single pair of genesmonogenic - of or relating to an inheritable character that is controlled by a single pair of genes
genetic science, genetics - the branch of biology that studies heredity and variation in organisms
heritable, inheritable - capable of being inherited; "inheritable traits such as eye color"; "an inheritable title"
References in periodicals archive ?
T1DM is different from monogenic diabetes mellitus, which is a relatively rare form of dysglycaemia.
Interestingly, she said, majority of such and other genetic causes of monogenic obesity were reported from cohort of Pakistani origin -- identifying genetic basis of severe obesity in children from consanguineous population.
Autosomal dominant polycystic kidney disease (ADPKD) is the most common life-threatening monogenic disease.
CF is the most frequent monogenic disease in Caucasians but is rare in Asian.
This condition is called monogenic diabetes and is diagnosed based on certain criteria, specifically, genetic testing.
Contract notice: Pa 2017-0-128: Supply of reagents and material for gene studies (hla-transplantation, Monogenic diseases and snps), Serological techniques and cell culture material, For the university hospital 12 de octubre.
AVXS-101 is a proprietary gene therapy candidate of a one-time treatment for SMA Types 1 and 2, designed to address the monogenic root cause of SMA and prevent further muscle degeneration by addressing the defective and/or loss of the primary SMN gene.
Genetic causes of monogenic heterozygous familial hypercholesterolemia: a HuGE prevalence review.
In this way, simple illustrations incorporate a considerable amount of information that provides the opportunity to determine genotype and phenotype probabilities for monogenic Mendelian traits without the need to draw Punnett square for every parental genotype combination.
This is especially important in terms of rare monogenic diseases (hereditary autoinflammatory diseases), which constitute a part of inflammation-based diseases that occur in childhood.
Mutations in some of the genes highlighted are also known to be associated with severe monogenic syndromes-conditions caused by a single genetic mutations-characterised by compromised muscle function.
Most rare diseases are genetic and include congenital abnormalities in growth, chromosomal monogenic syndromes, skeletal malformations, hereditary metabolic diseases, and hereditary cancers.