mosaicism


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Related to mosaicism: chimerism

mo·sa·i·cism

 (mō-zā′ĭ-sĭz′əm)
n.
A condition in which tissues of genetically different types occur in the same organism.

mosaicism

(məʊˈzeɪɪˌsɪzəm)
n
(Genetics) the occurrence of different types of cells side by side in the same organism

mo•sa•i•cism

(moʊˈzeɪ əˌsɪz əm)

n.
a condition in which an organism or part is composed of two or more genetically distinct tissues.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.mosaicism - the condition in which an organism has two or more cell populations that differ in genetic makeup
condition - a mode of being or form of existence of a person or thing; "the human condition"
Translations

mo·sa·i·cism

[MIM*158250]
n. mosaicismo, así como en un mosaico, los cromosomas son genéticamente mutadores diferentes que pueden establecer características distintas en humanos, tal como se muestra en la fisonomía por diferencias de sexo.
References in periodicals archive ?
Currently, Dr Chun is the professor and the senior vice president of Neuroscience Drug Discovery at Sanford Burnham Prebys Medical Discovery Institute as well as leads a team of 25 researchers in the study of genomic mosaicism (DNA sequence variation in brain cells) and lysophospholipid receptor signaling to understand and develop drug treatments for Alzheimer's disease, multiple sclerosis, and hydrocephalus.
The clinical and diagnostic implications of mosaicism in the neurofibromatoses.
The very low-level mosaicism for monosomy 13 (3/117) in this case supports this perspective.
Mosaicism refers to two or more genetically distinct cell populations when present in an individual derived from a single zygote.
With controlled timing, gene editing was restricted to only the paternal pathogenic mutation, resulting in 72% of all injected embryos having two normal copies of the gene in all cells without any mosaicism.
The lesion is caused by a post-zygotic somatic mutation in the KRAS or HRAS genes, which can lead to variable clinical mosaicism.
Researchers also noted that genetic mosaicism - a concern raised by earlier experimental efforts at gene editing - was virtually absent from the 42 embryos that were free of the disease-causing mutation.
The study also demonstrated a way to overcome a crucial problem in genome editing in embryos known as mosaicism.
Somatic mosaicism in the boy was supported by 8-lathosterol accumulation being less than expected in affecteds.
5,7) Since NS is caused by a somatic mosaicism mutation, there are several syndromic findings associated with NS depending on the timing of the mutations during development and whether single versus multiple tissues are affected.
These postzygotic events (which may include mutations, large-scale rearrangements, or aneuploidies) produce a varied distribution of altered genomes throughout the individual--a phenomenon known as mosaicism (De 2011).