Many process intermediates are common across companies and sharing mutagenicity
data on these compounds allows members to avoid duplicating costly and time consuming tests.
Revised methods for the Salmonella mutagenicity
dataset represents a binary classification problem where compounds are classified as mutagenic or non-mutagenic.
About two years ago, the NTP issued an interim warning that animal tests on both rats and mice indicated a strong probability of carcinogenicity and mutagenicity
The authors found mutagenicity
before and after the chlorination process and concluded that the pollution from the river that supplies water to the plant and DBP formation from the chlorination process were responsible for the mutagenicity
His current research interest is in the modulatory effects of natural products on the mutagenicity
of direct and indirect acting mutagens and the genotoxicity of pesticides.
In the first mutagenicity
assay--the bacterial mutation (Ames) assay--the mutagenic potential of E.
is a specific term that refers to a permanent, heritable change in the structure or amount of genetic material of an organism and includes gene mutations as well as structural and numerical alterations in chromosomes (Eastmond et al.
The new study details a comprehensive investigation of DBPs and mutagenicity
of water samples collected from two indoor pools, one disinfected with chlorine, the other with bromine.
The current International Conference of Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) recommends a battery of tests for the registration of pharmaceuticals, requiring an assessment of mutagenicity
in a bacterium, such as the Ames test, plus an in vitro test with cytogenetic evaluation of chromosomal damage in mammalian cells, such as the micronucleus test or an assessment of mutagenicity
in mammalian cells, such as the mouse lymphoma assay.
Data from in vivo transgenic assays is examined to help clarify specific pre-mutagenic adducts and the DNA repair functions and mutational events that may be involved in the mutagenicity
of human carcinogens.
No relationship was observed between mutagenic potency (revertants/ng mutagen) and antimutagenic potency when expressed in terms of the CHL dose/plate-inhibiting mutagenicity
by 50 percent (I50).