NRP-1 expression was directly correlated with myeloblast
percentage in the bone marrow of patients with AML, suggesting that NRP-1 correlates with tumor load.
Pluripotential stem cell Myeloid Progenitors Myeloblast
Monoblasts Marrow pool Mitotic Promelocytes Promonocytes precursors Myelocytes Post-mitotic Metamyelocytes bands Blood and Neutrophils, Monocytes tissue eosinophils and function basophils Innate Macrophage immunologic function Progenitors Megakaryocyte Erythroid Lymphoid Marrow pool Mitotic Maturing Normoblasts Pre-B precursors megakaryocytes Post-mitotic Reticulocytes B lymphoblast Blood and Platelets Erythrocytes B tissue lymphocytes function and plasma cells Haemostasis Oxygen Adaptive transport immunologic function Progenitors Marrow pool Mitotic Pro-T precursors Post-mitotic Lymphoblast Blood and T-lymphocytes tissue and NK cells function Fig.
Additionally, researchers assessed patients' bone marrow myeloblast
(blast, or immature white blood cells) counts.
Human acute myelogenous leukemia (AML) often arises from neoplastic transformation of pluripotent stem cells, resulting in cell immaturation at the recognizable levels of myeloblast
or promyelocyte stages.
During this period, the bone marrow myeloblast
count increases to 5 to 30%.
Immature granulocytes are defined as the collection of maturing granulocytic myeloid cells that have differentiated beyond the myeloblast
stage, but have not yet reached the stages of band form neutrophils, eosinophils, or basophils.
AML is characterized by a higher rate of abnormal hematopoietic stem cells in bone marrow than in MDS, and inefficient production of blood cells and peripheral organ failure due to migrating myeloblasts
Myeloid sarcoma, also known as chloroma, extramedullary myeloid tumor or granulocytic sarcoma, is an extramedullary tumor mass consisting of immature myeloid cells and/or myeloblasts
Per WHO classification, erythroleukemia is defined as [greater than or equal to] 20% myeloblasts
in the nonerythroid cell population with [greater than or equal to] 50% erythroid precursors in the bone marrow.
Myeloid sarcoma is defined as a tumor mass of myeloblasts
or immature myeloid cells involving an extramedullary anatomic site (1) and can occur in 3% to 8% of patients with acute myeloid leukemia (AML).
When considered primary internal malignancies of these patients, 6 patients were diagnosed with gastrointestinal malignancy, 4--with lung cancer, 4--with breast cancer, 3--with malignant melanoma, 1--with Ewing's sarcoma, 1--with acute myeloblasts
leukemia and 1 patient was diagnosed with prostatic cancer.
Of 44 children with Nl, 57% (n=25) had acute lymphoblastic leukemia (ALL), 18% (n=8) had non-Hodgkins lymphoma, 9% (n=4) had acute myeloblasts
leukemia (AML), 7% (n=3) had neuroblastoma, and 9% (n=4) had other solid tumors.