Cardiac troponin I (cTnI) mutation-caused myofibril
Ca2+ hypersensitivity has been shown to be associated with impaired diastolic function.
Water moves from the myofibril
into the extramyofibrillar spaces, where it eventually is lost from the muscle cell .
Histopathologic examination of the latter lesions revealed myofibril
necrosis with Zenker's degeneration and a heterophilic, lymphocytic, plasmacytic inflammatory reaction.
The level of serum cTn-I was increased in three to five hours, followed by continuous disruption and destruction of myofibril
, and cTn-I was constantly released, therefore, cTn-I is a serum marker of high sensitivity and specificity for reflection of myocardial cell damage.
The protein concentration of the myofibril
solution was determined by the biuret method (Gornall, Bardawill, & Maxima, 1949).
In muscle cells of the diseased crabs, condensation and margination of nuclear chromatin (Figure 5) injury of nuclear membranes, and mitochondria disintegration could be observed, moreover, myofibril
arrangement was loose and there were many vesicles between myofibril
The decrease in the number and diameter of fibers in malnourished young animals occurs due to the loss of myofibril
and consequently loss of fibers.
Benidipine prevents oxidative stress, inflammatory changes and apoptosis related myofibril
damage in isoproterenol-induced myocardial infarction in rats.
The SDS-PAGE pattern showed the presence of the myosin heavy chain (MHC) in the sarcoplasmic fraction, indicating high solubility of squid myofibril
proteins even at low ionic strength.
At autopsy multiple muscle biopsies showed extensive myofibril
loss, degeneration/regeneration, and calcific deposits.
Skipping of the exon with Ser14450fsX4 mutation in patient cardiomyocytes improved myofibril
assembly and stability and normalized expression of TTN regulated genes.
Our light and electron microscopic assessments demonstrated hypertrophy, vacuolar degeneration, focal necrosis, fibrosis, myofibril
disarray and partial fragmentation, distortion of mitochondrial structure, swelling hyperplasia, and local vacuolation in cardiomyocytes in rat with experimental diabetes and significant improvement of these abnormalities in diabetic rats after Zn treatment (Figure 1).