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The natural death of cells or tissues through aging, as distinguished from necrosis or pathological death.

nec′ro·bi·ot′ic (-ŏt′ĭk) adj.
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Development of a monoclonal antibody specific to granulocytes and its application for variation of granulocytes in scallop Chlamys farreri after acute viral necrobiotic virus (AVNV) infection.
Granuloma annulare (GA), which is characterized by necrobiotic dermal papules, is a benign inflammatory dermatosis of unknown cause.
12,23) The bias of necrobiotic lung nodules for peripheral or pleural locations and their ascribed waxing and waning course are of limited diagnostic value, even with known rheumatoid arthritis and subcutaneous necrobiotic nodules.
Histologic analysis demonstrated a palisading, necrobiotic granulomatous dermatitis with increased interstitial mucin (highlighted by colloidal iron stain shown in inset) consistent with granuloma annulare (Figure 3).
During subsequent stages, the lesion invades deeper into mesenchymal tissues, leading to accumulation of necrobiotic keratin debris in the newly formed central cavity; bone erosion and bone sequestra may also occur.
Other described histological reactions at injection sites include allergic contact dermatitis, lipogranulomas, local necrosis, sterile and infectious abscesses, necrotizing, necrobiotic and sarcoidal granulomas, cutaneous lymphoid hyperplasia, lupus profundus-like and morphea-like reactions.