oral ketoconazole, itraconazole, posaconazole, voriconazole, clarithromycin, telithromycin, indinavir, lopinavir, ritonavir, boceprevir, nelfinavir, saquinavir, telaprevir, nefazodone
, conivaptan) in patients taking YONDELIS.
2] Case reports have documented the successful treatment of hypersexual disorder with naltrexone, nefazodone
and valproic acid.
ketoconazole, itraconazole, clarithromycin, atazanavir, nefazodone
, saquinavir, telithromycin, ritonavir, indinavir, nelfinavir, voriconazole) or inducers (e.
The second-line agents also include antidepressants with weaker evidence of effectiveness, such as mirtazapine, or medications effective for PTSD but associated with rare but potentially dangerous side effects, such as nefazodone
because of its hepatotoxicity.
18-20) Emerging data suggest that the newer antidepressants such as escitalopram, (21,22) reboxetine, (23,24) nefazodone
, (25) venlafaxine, (26) mirtazapine (27-29) and buproprion (30-32) are promising alternatives.
Levin and her associates randomized 106 marijuana-dependent adults to nefazodone
, bupropion-sustained release, or placebo (Am.
Other recommended second-tier medications for PTSD, in addition to mirtazapine and adjunctive atypical antipsychotics, include the tricyclic antidepressants, nefazodone
, prazosin when prescribed for sleep problems or nightmares, and monoamine oxidase inhibitors.
concluded that the updated findings from 35 carefully vetted trials suggest that, compared with placebo, the four new-generation antidepressants (fluoxetine, venlafaxine, nefazodone
, and paroxetine) do not produce clinically significant improvements in depression in patients who initially have moderate or even severe depression.
Reduced drug elimination can result from hepatic and renal insufficiency, decreased hepatic perfusion (7), altered tissue binding properties and drug-drug interactions known to inhibit the CYP3A enzyme, for instance cimetidine, azole antifungals, clarithromycin, diclofenac, doxycycline, erythromycin, imatinib, isoniazid, nefazodone
, nicardipine, propofol, protease inhibitors, quinidine, telithromycin and verapamil.
A study was published which examined the effects of four antidepressants - Fluoxetine, Paroxetine, Venlafaxine and Nefazodone
- and it was claimed they were only slightly more effective than dummy pills in treating mild and moderate depression.
Those trials compared randomly assigned placebo treatment to treatment with any one of four antidepressants--fluoxetine (Prozac), venlafaxine (Effexor), nefazodone
(Serzone), and paroxetine (Paxil).
Antidepressant drugs including SSRIs, trazodone, nefazodone
, buspirone, clomipramine, venlafaxine, and duloxetine may be associated with the serotonin syndrome.