Mean creatinine remained stable at approximately 120 mumol/L but a majority of patients had co-existing conditions for which they were receiving nephrotoxic
Objective: To assess the extent of drug induced nephrotoxicity in laboratory animals for determining the role and extent of iatrogenic kidney damage in patients exposed to nephrotoxic
drugs in various clinical setups.
Ochratoxin is nephrotoxic
, which means that it damages the kidneys.
Outside doesn't tend to be as big a problem, as we cats are pretty smart, but it is possible for our outdoor friends to suffer the same nephrotoxic
effects after exposure to garden plants.
The company's technological approach enables the design and development of oral enzyme therapies that are designed to remain in the gastrointestinal tract, where the enzyme exerts its therapeutic effect by degrading certain nephrotoxic
metabolites, without being absorbed into the bloodstream.
2,4) Causes include major surgery, trauma, sepsis, pneumonia, circulatory shock, and treatments and diagnostic procedures such as nephrotoxic
drugs and imaging using contrast media.
Their use should be carefully monitored for any adverse effects, dosages adjusted according to the status of kidney function worked out by glomerular filtration rate (GFRe) for nephrotoxic
drugs, serum drug levels and kidney function estimations are employed.
Fluid support should be provided if using nephrotoxic
Nowadays, inhalational anesthetics are not considered nephrotoxic
The contribution of acute renal failure from medical causes has remained between 55-67% of all cases of ARF, whereas sepsis, nephrotoxic
drugs, open heart surgery in poor risk patients, cardiogenic shock and severe trauma following industrial and traffic accidents have emerged as the leading cause of ARF in developed countries (Rasmussen 1985, (10) Lein 1985, (11) Beaman 198513 and Schusterman 198715).
Testing also should be performed regularly for patients with CKD taking medications known to be nephrotoxic
or to have nephrotoxic
potential (Matzke et ah, 2011).
Patients' demographic characteristics, medical histories, underlying diseases, use of invasive equipment, side-effects associated with colistin, use of any other nephrotoxic
agents together with colistin, microorganism agents in nosocomial infections, and other data such as treatment outcomes were obtained from medical records.