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nondisjunction

   Also found in: Medical, Encyclopedia, Wikipedia 0.01 sec.
non·dis·junc·tion  (nnds-jngkshn)
n.
The failure of paired chromosomes or sister chromatids to separate and go to different cells during meiosis.

nondis·junction·al adj.

nondisjunction [ˌnɒndɪsˈdʒʌŋkʃən]
n
(Life Sciences & Allied Applications / Genetics) the failure of paired homologous chromosomes to move to opposite poles of the cell during meiosis
ThesaurusLegend:  Synonyms Related Words Antonyms
Noun1.nondisjunction - meiosis in which there is a failure of paired homologous chromosomes to separate; results in an abnormal number of chromosomes in the daughter cells
meiosis, miosis, reduction division - (genetics) cell division that produces reproductive cells in sexually reproducing organisms; the nucleus divides into four nuclei each containing half the chromosome number (leading to gametes in animals and spores in plants)


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The second "bit" is the elimination of the wild-type allele through nondisjunction, deletion, recombination, and/or chromosome loss and duplication This results in the primary mutation.
A possible explanation was suggested to be Y-chromosome nondisjunction, being more frequent in sperm of DBCP workers (Goldsmith et al.
 
 
 
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