NCL is a nucleolar phosphoprotein that is also among the most abundant nonhistone
proteins in the nucleus.
much more complex than other nonhistone
localities because they must
More and more nonhistone
proteins have been identified.
280) According to one study, only five residential buildings taller than fifteen stories have been erected in historic districts in "southern Manhattan" (281) since 1970--less than half the rate in nonhistone
In vitro studies at that time have indicated that ADP-ribosylation of chromatin occurs mainly in the histone H1 and H2B, and have also suggested nonhistone
proteins may undergo ADP-ribosylation.
Acetylation and deacetylation of nonhistone
dependent deacetylase, mainly deacetylating histones and many nonhistone
targets, including p53, FoxO1, FoxO3, Atg5, Atg7, Atg8, Ku70, NF[kappa]B, and PTEN, and is involved in tumor development, energy homeostasis, autophagy, DNA damage repair, and other important cellular processes .
HMGB1 is a highly conserved nuclear nonhistone
protein, which has been previously characterized as DAMP involved in inflammatory processes .
The above-mentioned SIRT1 is responsible for modifications of both histone and nonhistone
targets [124-126] and through modulation of its activity it brings a broad spectrum of S-nitrosylation and sulfhydration effect.
Deacetylation of nonhistone
proteins by HDACs and the implications in cancer.
Additionally, it is a nonhistone
nuclear protein, which is tightly linked to the cell cycle and is expressed in mid GI, S, G2, and M phases of proliferating cells but not in quiescent or resting cells of the GO and early GI phases.
Histone acetyltransferases (HATs) enzymes regulate the acetylation of histones and nonhistone