Altered recombination affects nondisjunction; nonrecombinant
chromosomes are susceptible to nondisjunction because of reduced connections among homologous chromosome pairs (Ferguson et al.
For analysis, sequences from the two mitochondrial genes were concatenated, since they are nonrecombinant
and evolve as a unit.
All sequences were confirmed as being nonrecombinant
by using Recombination Detection Program version 4 (26).
iVDPV1 isolates had 10-12 nucleotide substitutions from Sabin 1 vaccine virus in the 906-nucleotide VP1 capsid protein coding region.
Digestion of the recombinant plasmid produced two fragments of 4243 and 1 626 bp, but nonrecombinant
plasmid gave rise to only one DNA hand (Figure 2).
The probabilistic structure implies that the market evolves as a discrete, nonrecombinant
tree (hence, suitable for incomplete markets).
Second, the fixation of different alleles between the two species may be confounded by recombination, resulting in longer evolutionary timeframes for lineage assortment to occur than what would be expected for mtDNA, which is typically nonrecombinant
and clonally inherited.
Such drugs include recombinant and nonrecombinant
therapeutic products, vaccine products, allergenic products, in vivo diagnostics, plasma derivative products, blood and blood products, gene therapy products and so forth, which are all subject to the GMP requirements contained in section 501(a)(2)(B) FDCA.
It is, ironically, based on the well-established model of the USDA's own plant quarantine regulations for nonrecombinant
n] are the number of recombinant and nonrecombinant
genotypes, respectively, between two loci (Haldane and Waddington, 1931).
Nod+, also called the USDA Patented Strain, "is derived through nonrecombinant
means, so you don't have to worry about foreign genes in the bacterium's DNA," adds Kuykendall, with ARS' Molecular Plant Pathology Laboratory in Beltsville, Maryland.
Because recombinant factor is both expensive and sometimes scarce, patients may also receive "old-fashioned" nonrecombinant
products that are fractionated from human plasma.