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 (no͞o′klē-ə-sīd′, nyo͞o′-)
Any of various compounds, such as adenosine or guanosine, that consist of a sugar, usually ribose or deoxyribose, linked to a purine or pyrimidine base. Nucleosides are constituents of the nucleotides that make up nucleic acids.


(Biochemistry) biochem a compound containing a purine or pyrimidine base linked to a sugar (usually ribose or deoxyribose)
[C20: from nucleo- + -ose2 + -ide]


(ˈnu kli əˌsaɪd, ˈnyu-)

any of the class of compounds derived by the hydrolysis of nucleic acids or nucleotides, consisting typically of deoxyribose or ribose combined with adenine, guanine, cytosine, uracil, or thymine.
[< German Nucleosid (1909)]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.nucleoside - a glycoside formed by partial hydrolysis of a nucleic acid
adenosine - (biochemistry) a nucleoside that is a structural component of nucleic acids; it is present in all living cells in a combined form as a constituent of DNA and RNA and ADP and ATP and AMP
glycoside - a group of compounds derived from monosaccharides
inosine - a nucleoside that is formed by the deamination of adenosine; used in kidney transplantation to provide a temporary source of sugar
deoxyadenosine - a nucleoside component of DNA; composed of adenosine and deoxyribose
cytidine, deoxycytidine - a nucleoside component of DNA; composed of cytosine and deoxyribose
deoxyguanosine, guanosine - a nucleoside component of DNA; composed of guanine and deoxyribose
deoxythymidine, thymidine - a nucleoside component of DNA; composed of thymine and deoxyribose
References in periodicals archive ?
These inhibitory effects of BNO-1055 could be mimicked using pharmacological inhibitors and isoform-specific siRNAs targeting the equilibrative nucleoside transporters ENT1 and ENT2.
Chemists and pharmacists here explore some of the techniques used to synthesize nucleoside analogues.
According to Chimerix deal, Merck will have to develope and commercialize CMX157, an investigational oral nucleoside reverse transcriptase inhibitor which is presently in Phase I clinical development.
The transporter molecule, called a concentrative nucleoside transporter, works by moving nucleosides, the building blocks of DNA and RNA, from the outside to the inside of cells.
As PSI-938's resistance profile is different from other nucleoside/tides in development for HCV and it has a different metabolic pathway from pyrimidine analogs, such as RG7128 and PSI-7977, we believe PSI-938 could be potentially combined with other nucleosides in development to deliver a pan-genotype regimen.
Two large studies of HIV patients found a link between treatment with the nucleoside Ziagen (abacavir) and a higher risk of heart attacks (myocardial infarction, MI) and other heart disease.
The regimens for first-line therapy of HIV that are currently recommended by the Department of Health and Human Services are the protease inhibitor lopinavir and the nonnucleoside reverse transcriptase inhibitor efavirenz, each given with two nucleoside reverse transcriptase inhibitors.
Reverset was also shown to be effective in patients with virus resistant to other commonly used nucleoside analog reverse transcriptase inhibitors (NRTIs), including viruses harboring multiple thymidine analog mutations (TAMS), including the M41L and L210W mutations, and the L74V and M184V mutations.
Newer drugs are selecting for different types of resistance, especially in nucleoside reverse transcriptase inhibitors (NRTIs), so that there may not be large numbers of thymidine analog mutations (TAMs) developing in patients who have started therapy in recent years.
A major factor in the resistance of cells to antifolate cancer treatment involves nucleoside salvage from the extracellular media.
Approved March 14, 1996 for use alone or in combination with nucleoside analogues for the treatment of HIV infection in adults.
They bind to a cleft on the enzyme that normally locks onto a nucleoside, one of the building blocks of DNA.

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