has 8 histone molecules with 146 base pairs.
Among the topics are DNA repair by reversal of DNA damage, the maintenance of mitochondrial DNA integrity, nucleosome
dynamics as modular systems that integrate DNA damage and repair, trans-lesion DNA synthesis and mutagenesis in prokaryotes, and Deinococcus radiodurans and the biology of extreme radiation resistance.
The fundamental unit of chromatin is the nucleosome
, where 146 bp of DNA are wrapped around a histone octamer core, comprised of two of each core histones, H2A, H2B, H3 and H4, while its structure is completed with the association of H1 linker histone (Wolffe & Guschin, 2000).
Both DNA and protein components of the nucleosome
are subject to a variety of modifications that can influence chromatin conformation and accessibility.
A unit of DNA wrapped around a histone is called a nucleosome
, multiple nucleosomes
plus accessory proteins make up chromatin, and chromatin is packaged into chromosomes.
In fact, this periodicity has exactly the same size as a nucleosome
and serves as evidence that nucleosome
-protected DNA fragments are enriched in the circulation.
contains 146 bp DNA wrapped around an octamer of core histones.
I told Gerry I was interested in producing selenoproteins of the nucleosome
core particle--a major focus of his structural studies at Oak Ridge.
The detection of anti-nucleosome
antibodies was done by ELISA using nucleosomes
extracted from calf thymus chromatin as antigen (Inova Diagnostics Inc, USA).
The 16 articles here cover the physiochemical aspects and biological significance of polyelectrolytes, the solution behavior of nucleic acids, the compaction and decompaction of single DNA molecules, the interaction of DNA and surfactants in solution and with cationic polymers, the interactions of histones with DNA (in terms of nucleosome
assembly, stability, dynamics and higher order structure), opening and closing DNA, DNA to DNA interactions, DNA and other materials at liquid interfaces and solid complexes, DNA and cosolute interaction, simulation of polysions, cross-linked DNA gels and gel particles, DNA as an amphiphilic polymer, and structure-function studies of nanomaterials in gene deliver in lip-to-DNA interactions.
The DNA double helix winds around histone proteins, forming a nucleosome
In non-dividing eukaryotic cells, chromosomal DNA is wrapped around a nucleosome
core which consists of highly basic proteins called histones.