oligomerization


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o·lig·o·mer

 (ə-lĭg′ə-mər)
n.
A polymer consisting of at least 2 and as many as 100 monomers.

o·lig′o·mer′ic (-mĕr′ĭk) adj.
o·lig′o·mer′i·za′tion n.

oligomerization

(ˌɒlɪˌɡɒməraɪˈzeɪʃən) or

oligomerisation

n
(Chemistry) chem the production of an oligomer from monomers bonding together, or an occurrence of this formation
Translations
oligomérisation
References in periodicals archive ?
What does oligomerization mean for drug design and therapeutic efficacy?
Previous authors have emphasized the difficulty of measuring clones of FLCs, as their structures are heterogeneous and can be modified through pH, polymerization, and oligomerization (5-8).
BGC20-1178 (RS-1178) is a potent inhibitor of neuro-inflammation caused by beta-amyloid while BGC20- 0406 (RS-0406) is a small molecule inhibitor of amyloid oligomerization (the process by which amyloid self-associates to produce toxic aggregates) and has also been shown to disaggregate already formed amyloid fibrils.
Whatever the case, human synthetic NT-proBNP is a monomer, and the potential confounding issue of analyte oligomerization is not a problem for this analyte.
The goal of the funded study is to develop pharmaceuticals that can inhibit alpha-synuclein oligomerization and thus Lewy body formation and neurodegeneration.
Another study demonstrated that the N-terminal region of proBNP contains a leucine zipper-like sequence motif that may induce peptide oligomerization in plasma under physiologic conditions, producing either a trimer or tetramer of proBNP and a trimer of NT-proBNP (2).
These measurements support the hypothesis of oligomerization of the glycoprotein.
It is nevertheless important to emphasize that such oligomerization may have a major influence on antibody detection and assay performance.
Because real-time fluorescence monitoring was not available on the plate reader, we used agarose gel analysis and signal measurements of the Universal Amplifluor-labeled PCR amplicons to assess the contribution of primer oligomerization in no-template samples to the fluorescent signals.
Moreover, the prosequence contains a leucine zipper-like sequence motif that has been reported to induce oligomerization of the N-terminal fragments of proBNP and pro-atrial natriuretic peptide (proANP) in plasma (31).
The protein consists of a highly charged acidic amino-terminal domain, which can interact with components of the transcriptional machinery, and a highly charged basic carboxy-terminal region, which can mediate oligomerization, nuclear localization, and possibly the recognition of damaged DNA.