oncogene


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Related to oncogene: Cancer research

on·co·gene

 (ŏn′kə-jēn, ŏng′-)
n.
1. Any of various mutated genes that cause the transformation of normal cells into cancerous cells.
2. Any of various viral genes that transform host cells into cancerous cells.

[Greek onkos, mass, tumor; see oncology + gene.]

oncogene

(ˈɒŋkəʊˌdʒiːn)
n
(Genetics) any of several genes, first identified in viruses but present in all cells, that when abnormally activated can cause cancer
[C20 from Gk onkos mass, tumour + gene]

on•co•gene

(ˈɒŋ kəˌdʒin)

n.
any gene that is a causative factor in the initiation of cancerous growth.
[1965–70]

on·co·gene

(ŏn′kə-jēn)
A gene containing a mutation in its DNA that causes normal cells to turn into cancerous ones. See Note at cancer.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.oncogene - a gene that disposes normal cells to change into cancerous tumor cellsoncogene - a gene that disposes normal cells to change into cancerous tumor cells
cistron, gene, factor - (genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors"
Translations
References in periodicals archive ?
It will allow the investigators to develop drugs capable of preventing oncogene activation and activity in the body.
Thus, they discovered that tumor cells can eliminate the oncogene identified by drugs that specifically target them, and regain the oncogene, which makes them vulnerable to the original therapy, after treatment is stopped.
The results published in our Cell report, in collaboration with David Brown's group at Ambion, showed for the first time that miRNAs could regulate cellular oncogene mRNAs.
The oncogene NF-kappaB on the other hand, promotes cell division resulting in the synthesis of substrates for cell division.
The briefer articles review studies on an oncogene implicated in normal as well as cancerous stem cells, and the growing interest in the notion of modules in biological networks.
A team of Kyoto University researchers have succeeded in reprogramming human skin cells to create induced pluripotent stem cells, or iPS cells, without using an oncogene, a cancer-inducing gene, the U.
He led an international team that discovered that the melanocyte master regulator MITF (microphthalmia-associated transcription factor)--which normally regulates melanocyte differentiation and survival--is also a lineage survival oncogene figuring prominently in metastatic melanoma (Nature 2005; 436:117-22).
Mutations in genes linked to cancer do not occur randomly but arise most often in certain regions of the oncogene (cancer-causing gene).
Weinberg had cloned the ras oncogene, which was activated by chemicals and that was being studied by a number of different laboratories .
Mice given the oncogene developed aggressive, fatal forms of lymphoma.
Avalon's amplified oncogene discovery program has used high-resolution molecular cytogenetics to generate a proprietary database of cytogenetic amplifications.