2, 2015 /PRNewswire/ -- ApeX Therapeutics, a biotechnology company focused on developing novel compounds to treat cancer, today announced the presentation of two posters describing preclinical efficacy of drug candidate APX3330 in models of pancreatic cancer targeting the novel inhibition of multiple oncogenic
transcription factors associated with the APE1/Ref-1 protein, at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics to be held in Boston, MA on November 5-9, 2015.
We have discovered a metabolic imbalance that is oncogenic
or pro-cancer," Dr.
Due to this modular architecture, MPT families are of particular interest to comparative studies of oncogenic
Anne Schuchat referred to the expanded coverage of additional oncogenic
HPV types with the 9-valent vaccine as "a milestone.
DNA was extracted from the tampon specimens and tested for any of the 15 high-risk viral types (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73, 82), HPV 16 and 18 being the two most oncogenic
Chickens may be infected with 3 different oncogenic
viruses: avian leukosis virus (ALY), reticuloendotheliosis virus (REV), and Marek's disease herpesvirus (MDV).
Stewart became medical director of the NCI Laboratory of Oncology and spent the remainder of her life researching several oncogenic
Mina Bissell, Distinguished Scientist with Berkeley Lab's Life Sciences Division, said that through a series of painstaking analysis, they discovered two new pathways through which increased uptake of glucose could itself activate other oncogenic
Curcumin treatment significantly resulted in reduced matrix metalloproteinase 9 activity and downregulation of cellular matriptase, a membrane-anchored serine protease with oncogenic
roles in tumor formation and invasion.
While most of the HPV infections disappear naturally, persistent infection with oncogenic
HPV will definitely lead to cervical cancer.
Here neurologists and other biomedical researchers explain in some detail how PAKs--particularly the oncogenic
kinases PAK1 and PAK4 and their blockers--may control various aspects of life and health, and how mammalian PAKs have functionally evolved from their ancestral origins in unicellular organisms such as yeast and amoebas through a series of mutations over millions of years.
mutations in genes encoding key downstream effectors within the EGFR signalling pathways may also be responsible for resistance to EGFR-targeted MoAbs.