orexin


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o·rex·in

 (ô-rĕk′sĭn)
n.
Either of two neuropeptide hormones synthesized in the hypothalamus that regulate sleep and wakefulness and whose dysfunction causes narcolepsy. Also called hypocretin.

[Greek orexis, appetite (from the view that orexin stimulates appetite; see anorexia) + -in.]

orexin

(əˈrɛksɪn)
n
a hormone that promotes wakefulness and stimulates the appetite
Translations
Orexin
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References in periodicals archive ?
Lemborexant, a dual orexin receptor antagonist small molecule compound that inhibits orexin neurotransmission by binding competitively to the two subtypes of orexin receptors (orexin receptor 1 and 2, acts on the orexin neurotransmitter system and is believed to regulate sleep and wake by dampening wakefulness without impeding the ability to awaken to external stimuli.
Lemborexant acts on the orexin neurotransmitter system and is believed to regulate sleep and wake by dampening wakefulness without impeding the ability to awaken to external stimuli.
Yan said the research team is investigating one potential site in the rodents' brains - a group of neurons in the hypothalamus that produce a peptide called orexin that's known to influence a variety of brain functions.
Dec 10, 2014: Eisai Demonstrates Efficacy of Investigational Dual Orexin Receptor Antagonist E2006 in Sleep Initiation and Maintenance 88
announced today that the latest data on its oral dual orexin receptor antagonist lemborexant and its oral beta secretase cleaving enzyme (BACE) inhibitor elenbecestat will be presented at the 10th Clinical Trials on Alzheimer's Disease (CTAD), taking place in Boston, the United States, from November 1 to 4.
In the light of this, the orexin neuropeptides are part of a network able to increase EE through modulation of BAT thermogenesis which can be a target to new strategies to reduce the incidences of overweight and obesity.
Increased orexin expression promotes sleep/wake disturbances in the SOD1-G93A mouse model of amyotrophic lateral sclerosis.
2011): Air-CCAPR1-Like (similar to cardioacceleratory peptide receptor), Air-AAR1-Like (similar to allatostatin-A receptor), and Air-OX2R1-Like (similar to orexin receptor type 2).
Idorsia Ltd's Phase 2 study investigating the dual orexin receptor antagonist ACT-541468 (DORA) in insomnia, with zolpidem as an active reference, has seen positive results, the company announced on Friday.
It is an attempt at unraveling possible unexplained areas entailing two neuromodulators, orexin, and nociceptin, to look into their respective effects on the HPA axis, psychological stress, and sepsis-related stress responses.
Medications reviewed included eszopiclone, zaleplon, Zolpidem, orexin receptor antagonist, melatonin, ramelteon, and benzodiazepines.