In the osteoblastic
type, as seen in our patient, the osteoid is deposited in a fine, branching, lace-like, or coarsely trabecular pattern.
SR has demonstrated to stimulate bone formation, which may be beneficial for Osseo integration, and it has also been reported to stimulate preosteoblastic and osteoblastic
cell replication and synthesis of collagenous matrix.
WHO in the classification of odontogenic tumours (2005) defined JOF as "an actively growing lesion well demarcated from surrounding bone that is composed of cell-rich fibrous tissue containing bundles of cellular osteoid and bony trabeculae without osteoblastic
SATB2 has also been shown to be highly expressed in tumors of osteoblastic
differentiation, including osteosarcomas and several benign bone tumors, and in some soft-tissue malignancies, including liposarcomas.
The recombinant protein was renatured by stepwise dialysis, purified by Ni-NTA affinity chromatography, and analyzed for the effects on cell proliferation by the MTT assay and osteoblastic
differentiation by-alkaline phosphatase (ALP) activity.
sup] On the other hand, BMP7 regulates expression of smooth muscle a-actin, preventing the osteoblastic
Thyroid hormones increase the osteoblastic
activity which leads to demineralization of bone than its mineralization.
In particular, the patent covers methods to manufacture differentiated and biologically active osteoblastic
cells from bone marrow stem cells, through a specific combination of growth factors.
Supplement intake with zinc has stimulatory effects on osteoblastic
bone formation and suppressive effects on osteoclastic bone resorption through zinc-finger transcription factor Osterix (OSX).
Osteitis deformans, also known as Paget's disease, is characterized by accelerated osteoclastic activity followed by ineffective osteoblastic
activity resulting in a deformed and fragile bone.
Porphyromonas gingivalis LPS inhibits osteoblastic
differentiation and promotes pro-inflammatory cytokine production in human periodontal ligament stem cells.
H & E decalcified section shows an admixture of irregularly shaped immature and mature bony trabeculae with osteoblastic
rimming and there is presence of osteocytes within the lacunae.