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osteoclast
(redirected from osteoclastic)

   Also found in: Medical, Encyclopedia, Wikipedia 0.01 sec.
os·te·o·clast  (st--klst)
n.
1. A large multinucleate cell found in growing bone that resorbs bony tissue, as in the formation of canals and cavities.
2. An instrument used in surgical osteoclasis.

[osteo- + Medieval Latin -clasts, breaker (from Late Greek -klasts, from Greek klastos, broken, from kln, to break).]

oste·o·clastic adj.

osteoclast [ˈɒstɪəʊˌklæst]
n
1. (Medicine / Surgery) a surgical instrument for fracturing bone
2. (Life Sciences & Allied Applications / Physiology) a large multinuclear cell formed in bone marrow that is associated with the normal absorption of bone
osteoclastic  adj

osteoclast  (st--klst)
A specialized bone cell that absorbs bone, allowing for the deposition of new bone and maintenance of bone strength. Osteoclasts secrete enyzmes that dissolve the matrix of old bone tissue and acids that dissolve bone salts, which contain calcium and phosphorus. Except in growing bone, the rate of bone deposition and bone absorption equal each other so that bone mass remains constant. A mass of osteoclasts absorbs bone from the outer surfaces inward for about three weeks. The osteoclasts are then converted into osteoblasts that form new bone to fill in the cavities. See also osteoblast.
ThesaurusLegend:  Synonyms Related Words Antonyms
Noun1.osteoclast - cell that functions in the breakdown and resorption of bone tissue
bone cell - a cell that is part of a bone


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Currently FDA-approved bisphosphonates, including Fosamax (alendronate), Actonel (risedronate), Didronel (etidronate), Boniva (ibandronate), and Reclast (Zometa) (zoledronate), are designed to strengthen bone by inhibiting normal osteoclastic bone resorbing activity, which slows the loss of bone mineral density (BMD), allowing the trabecular architecture to stabilize.
Bone turnover improved selectively in women >70 years old, as assessed by the dualenergy x-ray absorptiometry (DEXA) technique and the decrease of osteoclastic activity.
 
 
 
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