Bone marrow-derived mesenchymal stem cells (bMSCs) are multipotent adult stem cells, whose osteogenic
differentiation potential has been reported in several in vitro studies, have become an important source of cells for engineered tissue repair and cell therapy (4).
differentiation property of the BMSCs was determined by seeding the cells at passage 3 and 80% confluency into 6-well plates for 21 days adding glucose DMEM supplemented with 100 nM of dexamethasone (Sigma, USA), 0.
According to the company, Doxophos has been approved for use in the treatment of acute lymphoblastic leukaemia, acute myeloblastic leukaemia, chronic leukaemia, Hodgkin's disease and non-Hodgkin's lymphoma, multiple myeloma, osteogenic
sarcoma, Ewing's sarcoma, soft tissue sarcoma, neuroblastoma, rhabdomyosarcoma, Wilms' tumour, breast carcinoma, endometrial cancer, ovarian carcinoma, germ cell tumours, prostatic carcinoma, lung cancer, gastric carcinoma, head and neck cancer and thyroid carcinoma.
To improve osteogenic
differentiation of adipose-derived mesenchymal stem cells (AD-MSCs), this step can be performed in vitro before clinical use (LIU et al.
The research team reported that red-light absorbing carbon nitride (C3N4) sheets lead to remarkable proliferation and osteogenic
differentiation by runt-related transcription factor 2 (Runx2) activation, a key transcription factor associated with osteoblast differentiation.
Osteomas are relatively rare benign osteogenic
neoplasms characterized by the proliferation of compact and/or cancellous bone.
While Plasticell's osteogenic
media formulation has been licensed to MilliporeSigma for research use only--marketed as OsteoMAX-XF--Plasticell has retained rights to use the formulation and derivatives to develop therapeutic products, such as a cell-based therapy for repair of bone fractures.
An Osteoma is a benign osteogenic
tumor, histologically characterized by compact or cancellous bone proliferation.
We propose to investigate the extrinsic microenvironment components synthesized by young, embryonic-like osteogenic
cells derived from human induced pluripotent stem cells, and test their potential to enhance the function of endogenous bone and vascular cells.
To determine the osteogenic
differentiation, cells from passage 5 were seeded into 6 well plates.
Bearing in mind that previous research has indicated a proosteogenic effect of metformin on BMSCs or commitment cell lines in vitro, we became interested in the effect of metformin on the osteogenic
potential of mice, as well as the effects of metformin on bone in vivo.
Not only did increased stress relaxation dramatically increase early osteogenic
differentiation but those cells continued to grow as bone cells weeks after their initial differentiation and formed an interconnected mineralized matrix rich in collagen, key structural features of bone.