A new mouse model known as the Diversity Outbred
better reflects the genetic diversity of the human population, offering intriguing possibilities for safety assessment.
These results indicated that outbred
mice may be less sensitive than inbred mice and stress is an individually sensitive and variable factor that appears to be body weight or age dependent.
Italian fiber varieties) are obligate outbred
, and the method used to multiply them (open-field pollination) approaches a random-mating condition.
For instance, resource allocation to the seeds may differ between inbred and outbred
maternal plants, and may, therefore, affect the performance of the offspring.
The Company utilized unique approaches in creating 9 diagnostic patent submissions and it developed proprietary know-how managing its own 10,000+ outbred
2011), or by using populations of outbred
mice (Yalcin et al.
Recent advances in statistical methods in outbred
populations have made it possible for QTL mapping in virtually any type of population (Xu and Atchley, 1995: Knott et al.
25 had a 36% (95% CI: 13-60%) lower probability of hatching than eggs of outbred
Edward Bilsky of the University of New England College of Medicine made a presentation entitled "Antidepressant and Locomotor Effects of Milnacipran in Outbred
and Inbred Strains of Mice" at the Society for Neuroscience meeting in Orlando, Fla.
We estimate carcinogenic potency by fitting a dose-response function to tumor incidence data from groups of 50 inbred rodents--or from somewhat larger groups of working-age people--and simply pronounce the group potency estimate relevant for hundreds of millions of outbred
humans, who among them exhibit every conceivable genetic polymorphism, co-exposure, psychological stress factor, and disease status that is deliberately engineered out of the laboratory or attenuated in the epidemiological raw material.
Accuracy of detection of major genes segregating in outbred
population by Gibbs sampling using phenotypic values of quantitative traits.
Following Houle (1994), I rather consider that the mean fitness of a genotypic class depends on the relative proportions of inbred versus outbred
individuals within this class.