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COMPARE analysis of the toxicity of an iminoquinone derivative of the imidazo(5,4-qbenzimidazoles with NAD(P)H:quinone oxidoreductase 1 (NQ01) activity and computational docking of quinones as NQ01 substrates.
Raxone (idebenone), a synthetic short-chain benzoquinone and a cofactor for the enzyme NAD(P)H:quinone oxidoreductase (NQO1), is capable of transferring electrons directly onto complex III of the mitochondrial electron transport chain, thereby circumventing the complex I defect, reducing and scavenging ROS and restoring cellular energy levels in retinal ganglion cells and promoting recovery of visual acuity.
In brief, it is based on the assumption that under certain conditions the activity of a cellular enzyme, NAD(P)H-dependent oxidoreductase, may reflect the number of viable cells present in a culture.
Xanthine Oxidoreductase (XOR) is a rate-limiting enzyme of the purine degradation pathway, oxidizing hypoxanthine into xanthine and xanthine into uric acid.
Furthermore, there is hydroxylamine oxidoreductase (HOA) enzyme, located in the periplasmic membrane which has a role in transforming NH2OH into N[O.
The P450 oxidoreductase *28 SNP is associated with low initial tacrolimus exposure and increased dose requirements in CYP3A5-expressing renal recipients.
Topical application of an extract delivering 100 nmol sulforaphane/cm(2) increased the protein levels of NAD(P)H:quinone oxidoreductase 1 (NQO1), glutathione S-transferase A1, and heme oxygenase 1, three representative phase 2 enzymes, in mouse skin epidermis.
2] generation at the cell membrane by pretreating the cells with the specific NADPH oxidoreductase inhibitor DPI 30 mm prior to the addition of 10-150 [micro]M l,2-NQ.
DszD is flavin oxidoreductase and absoloutely required in the reaction catalysed by DszC and DszA enzymes.
Regulation of human NAD(P)H:quinone oxidoreductase gene.
Glucose meters that use strips containing glucose dehydrogenase pyrroloquinolinequinone (GDH-PQQ) or glucose dye oxidoreductase as the enzymatic assay are susceptible to this interaction (Health Canada, 2008).