p53


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p53

 (pē′fĭf′tē-thrē′)
n.
1. A protein that regulates normal cell growth and proliferation and prevents unrestrained division of cells whose DNA has been damaged, as from ultraviolet or ionizing radiation. The absence of functional p53, usually resulting from a genetic mutation, increases the risk of developing various cancers.
2. The tumor suppressor gene that codes for this protein. Also called TP53.

[p(rotein) 53, from its apparent molecular mass of 53 kilodaltons as extrapolated from its mobility during electrophoresis.]
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Many publications have used immortalized cells as MSC surrogates, but they may not mean much if they don't have functionally accurate p53," said Siddaraju Boregowda, one of the study's two lead authors.
The p53 protein is a critical tumor suppressor in the cell, and genetic mutations that occur in cancer cause a loss of its function in regulating proliferation arrest and cell death.
Cells with loss of p53 function and abnormal expression of p53 are speculated to undergo malignant transformation.
Keywords: S100B, P53, brain tumours, interrelationship of biomarkers.
The report provides comprehensive information on the Cellular Tumor Antigen P53 (Tumor Suppressor P53 or Antigen NY-CO-13), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
Accordingly we examined the expression of P53 and Caspase 3 in the livers of mice having transperitoneally injected Ehrlich Ascites carcinoma cells and treated with Tetrodotoxin.
dependent histone deacetylase, and the p53 gene was the first SIRT1 deacetylation nonhistone target to be discovered [4, 5].
Recent data have shown that, in addition to losing transcriptional function, mutant P53 gains oncogenic functions termed GOF (gain of function) that drive cell migration, invasion, and metastases.
However, this mutated protein could not interfere with binding of RAD51 to GST-WT p53 in MDA-MB-468 cell line by in vitro experiment.
Immunohistochemistry (IHC) for P53 and Ki-67 were performed on representative blocks of paraffin embedded tissue.
High prevalence of p53 alterations have been investigated in HCC as a consequence of chronic hepatitis B.