Complications resulting from measles, such as pneumonia, encephalitis, and subacute sclerosing panencephalitis
, sometimes occur a few years after the illness (14).
A very rare example of this is subacute sclerosing panencephalitis
, that may develop some years after an attack of the measles.
The disease can also cause a serious brain complication known as subacute sclerosing panencephalitis
(SSPE), which is fatal.
Subacute sclerosing panencephalitis
(SSPE) is a rare, measles-mediated encephalitis associated with progressive neurologic deterioration and death.
The neurologic complications of vaccination are fortunately rare, but can include panencephalitis
, acute disseminated encephalomyelitis, Guillain-Barre syndrome, cerebellar ataxia, parkinsonism, transverse myelitis, Bell palsy, myasthenia gravis, neuropathy, sensorineural hearing loss, seizures, mental retardation, and autism.
Problems include ear infections, vomiting and diarrhoea, pneumonia, meningitis, encephalitis, serious eye disorders, heart and nervous system problems and a progressive and fatal brain infection called subacute sclerosing panencephalitis
- sometimes many years after the first bout of measles.
HIV-associated neuro-cognitive disorder EBV: primary CNS lym-phoma JC virus: PML [not equal to] Prions: spongiform ence- phalopathy Spinal Acute viral HIV-1 vacuolar cord myelitis myelopathy ADEM * HTLV-1 myelopathy * Acute disseminated encephalomyelitis [dagger] Subacute sclerosing panencephalitis
[not equal to] Progressive multifocal leucoencephalopathy.
Neuroprogressive disease of postinfectious origin: a review of a resurging subacute sclerosing panencephalitis
It has been shown that MV induces mitochondrial structural abnormalities in dendrites during persistent infection of the brain termed subacute sclerosing panencephalitis
(SSPE)28 and also has been associated with apoptosis.
25) In this study, disease-specific deposits of IgG or activated complement that correlated with the known distribution of either foreign antigen or autoantigen, were detected in virus-infected cells in progressive multifocal leucoencephalopathy, subacute sclerosing panencephalitis
and cytomegalovirus encephalitis; in glial limiting membranes in neuromyelitis optica; and in senile plaques in Alzheimer's dementia.
Susanne Prendergast got measles when she was just two - but it was eight years before she started to show signs of the rare measles-relatebrain disorder Subacute Sclerosing Panencephalitis
in the summer of 1982.
Some sufferers have even been known to develop a progressive and fatal brain infection known as subacute sclerosing panencephalitis
, which may not develop until years after the bout of measles.