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para-aminosalicylic acid

   Also found in: Medical, Encyclopedia, Wikipedia 0.01 sec.
par·a-a·mi·no·sal·i·cyl·ic acid  (pr--mn-sl-slk, m-n-)
n. Abbr. PAS
A bacteriostatic agent, C7H7NO3, prescribed for the treatment of tuberculosis. Also called aminosalicylic acid.


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tuberculosis isolates resistant to streptomycin, 119 (65%) to ethambutol, 103 (56%) to rifabutin, 79 (43%) to pyrazinamide, 23 (13%) to amikacin, 20 (11%) to a fluoroquinolone, 19 (10%) to capreomycin, 36 (19%) to ethionamide, 15 (8%) to para-aminosalicylic acid, 9 (5%) to cycloserine, 3 (2%) to kanamycin, and 1 (<1%) to linezolid.
A daily regimen of 12,000 mg para-aminosalicylic acid, 800 mg ofloxacin, 750 mg cycloserine, 750 mg ethionamide, 150 mg thiacetazone, and 1,000 mg amikacin was administered for 2 years, with the diagnosis of multidrug-resistant tuberculosis.
On the basis of these results, on October 26, 2007, he was empirically prescribed a regimen of second-line drugs: capreomycin, para-aminosalicylic acid, cycloserine, ethionamide, and ciprofloxacin.
 
 
 
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