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Related to paracrine: Paracrine signaling


 (păr′ə-krĭn′, -krēn′)
Of or relating to the release of locally acting substances from endocrine cells.

[German parakrin : Greek para-, para- + Greek krīnein, to separate; see krei- in Indo-European roots.]


(Physiology) relating to a hormone whose release only affects tissue surrounding the gland that secreted it
References in periodicals archive ?
Various in vitro and in vivo studies have demonstrated that ADSCs mediate several aspects of the healing cascade through the paracrine secretion of growth factors and cytokines.
Stromal antiapoptotic paracrine loop in perineural invasion of prostatic carcinoma.
6) also mentioned that HRS cells are sustained by an autocrine and/or paracrine production of several cytokines, including IL-5, IL-8, IL-9, CCL- 5, and CCL-28.
While it was first identified and classically referred to as a highly coordinated endocrine system, recent research has identified the RAAS system as also being an autocrine and paracrine system.
24) Visceral adipose tissue, a metabolically active endocrine and paracrine organ, secretes many proinflammatory and proatherogenic cytokines.
To examine paracrine signaling they used a microchannel device developed by our long-time collaborator and friend, Dave Beebe , also at UW-Madison, that relies on the passive pumping technology used in BellBrook's iuvo[R] Microchannel plates (URL: http://www.
Ovulation rate is determined by a complex exchange of endocrine signals between the pituitary gland and the ovary and paracrine and probably autocrine signals in ovarian follicles involving the oocyte and its adjacent somatic cells.
Estrogens reduce bone resorption directly by inhibiting osteoclasts and indirectly by suppressing osteoblastic production of various proresorptive paracrine factors such as interleukin (IL)-1 (3, IL-6, and tumor necrosis factor a (TNFa).
AMH is expressed in normal endometrium and suggested to negatively regulate cellular viability via paracrine function.
It is highly likely that miRNAs act as messengers to communicate in a paracrine manner with neighboring or distant cells, although the exact mechanisms of this have yet to be elucidated.
Placental estrogens and [beta]-hCG act in autocrine, paracrine, and endocrine manners on the trophoblast and fetal unit.
They may communicate directly through juxtacrine signaling, over short distances through paracrine signaling and over large distances through endocrine signaling.