pargyline


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pargyline

(ˈpɑːdʒɪˌliːn)
n
(Pharmacology) pharmacol a monoamine oxidase inhibitor used to treat hypertension and depression
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Homogenates were distributed in 96-well dark microplates (at 50 [+ or -] 5 [micro]g protein/well) and incubated at 37[degrees] C in the dark for at least 30 min in 200 [micro]L final volume after a 30 min preincubation without (control) or with 1 mM pargyline or semicarbazide to inhibit MAO or SSAO activity, respectively, or even with both reference inhibitors to abolish all AO activity.
1,3-Ditolylguanidine (DTG), clozapine, GBR12909, pargyline and dopamine were purchased from Sigma Chemical Co.
Central serotonin level dependent changes in body temperature following administration of tryptophan to pargyline and harmaline- pre treated rats.
Exogenous analogues of these compounds are antidepressants such as pargyline, deprenyl, and so on.
Addition of the monoamine oxidase inhibitor pargyline together with BH4 also did not increase serotonin levels (n = 3, Fig.
Certain medications (phenelzine, pargyline, corticosteroids) can also precipitate similar symptoms, as can a host, of disorders of the hepatic, renal, hematologic, and endocrine systems, and malignancies.
Isoform-specific irreversible inhibitors include clorygline, which is a research compound specific for MAO-A, and the two B-selective inhibitors selegiline and pargyline.
Three studies used a monoamine oxidase inhibitor (deprenyl and pargyline [Eutonyl]), and the others tested more commonly used antidepressants, including desipramine (Norpramin), bupropion (Wellbutrin), venlafaxine (Effexor), fluoxetine (Prozac), and sertraline (Zoloft).
8, at 37[degrees]C for 30 min in the absence or in the presence of the MAO inhibitors pargyline (100 [micro]M; Sigma-Aldrich, St.
50] values of positive control, L-deprenyl (an MAO-B inhibitor) and pargyline (a nonselective MAO inhibitor), were 0.