parp


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parp

(pɑːp)
vb (intr)
to make a honking sound like a horn
n
1. a honking sound like a horn, or an instance of this
2. the sound of flatulence, or an instance of this
References in periodicals archive ?
In vitro studies have shown that Lynparza-induced cytotoxicity may involve inhibition of PARP enzymatic activity and increased formation of PARP-DNA complexes, resulting in DNA damage and cancer cell death.
The overlap in immuno-biology linked to these agents supports the potential for synergy of PARP inhibition and PD-1 blockade.
AstraZeneca global medicines development executive vice president and chief medical officer, Sean Bohen, said, 'Today's approvals validate more than 10 years of dedicated research behind LYNPARZA, the world's first PARP inhibitor, which now provides oncologists with the greater flexibility for use in terms of treatment settings.
The PARP family of enzymes hold a vital role in the repair of DNA and the stabilization of the human genome through the repair of single-stranded breaks (SSB) in DNA.
As with platinum, previous studies have shown that PARP inhibitors selectively benefit individuals with pathogenic variants in BRCA1 or BRCA24n~13 and, as such, illustrate the benefits of personalized medicine in the selection of therapies based on individual tumor biology and patient characteristics.
The PARP directors asked the president of SSS why pensions were lower than the cost of living.
As many as eight PARP inhibitors are currently being developed, and major companies have invested millions of pounds in clinical trials.
Audeh said at least seven other PARP inhibitors are in development and testing for cancers associated with BRCA gene mutations, and for others that may stem from similar mutations.
Tumors with the mutated BRCA phenotype are particularly sensitive to PARP inhibitors (8) because PARP inhibition leads to double-strand DNA breaks that cannot be repaired in BRCA mutated tumors.
In this paper, we characterize, localize, and assign a possible role to a cytoplasmic PARP in the brain of Octopus vulgaris.
The acronym PARP stands for "poly ADP ribose polymerase.
PARP inhibitors are designed to treat inherited forms of breast and ovarian cancer marked by a particular defective gene.