Cell-selective targeted drug delivery has emerged as one of the most significant areas of biomedical engineering research, to optimize the therapeutic efficacy of a drug by strictly localizing its pharmacological activity to a pathophysiologically
relevant tissue system.
The best treatment for these patients will likely involve multiple modalities/combination therapy, as there is no one major pathway pathophysiologically
," said Dr.
, those signs are primarily due to a mass effect compromising the gastrointestinal lumen or associated mesenteric arteries, rather than infiltration into the gut itself.
Whereas the imprecision of a preclinical assay is important in distinguishing diseased from healthy individuals or one pathophysiologically
important state from another, a narrow analytical dynamic range can make this difficult.
Spina bifida occulta or closed spina bifida refers to a range of rare but characteristic congenital abnormalities involving the lower spinal cord, such as a lipoma, myelocystocele or split cord; usually there is an overlying cutaneous abnormality (such as a subcutaneous lipoma, naevus or hairy patch) and pathophysiologically
the spinal cord is tethered and vulnerable.
Statistically and pathophysiologically
, we have come to understand the adverse contributions of inflammation to CVD.
Stimulation of eryptosis may be pathophysiologically
, frailty represents a state of increased vulnerability to poor resolution of altered homoeostasis after a stressor event.
, hyponatremias are classified into two groups: hyponatremia due to non-osmotic hypersecretion of vasopressin (hypovolemic, hypervolemic, euvolemic) and hyponatremia of non-hypervaso-pressinemic origin (pseudohyponatremia, water intoxication, cerebral salt wasting syndrome) (4).
Hypocalcemia, phosphate retention, changes in vitamin D metabolism, decrease of PTH degradation, changes in calcium regulation are led to secondary hyperparathyroidism pathophysiologically
Thus, there is a need for effective methods to identify biological pathways that are pathophysiologically
related to birth defects.
In this project I propose to specifically address the effect of physical confinement on normal and cancer cells that are dividing and migrating, using new pathophysiologically
relevant in vitro approaches.