patients in our Phase II clinical trial in bullous pemphigoid
, an orphan auto-immune disease of the skin, and starting to enroll patients in the Phase II clinical trial in moderate to severe ulcerative colitis, a serious immuno-inflammatory condition of the gastro-intestinal tract.
Food and Drug Administration (FDA) has approved its Investigational New Drug (IND) application for its first in class, lead product candidate, Bertilimumab, to treat Bullous Pemphigoid
The dipeptidyl peptidase-IV inhibitors are the newer drugs linked to the most potentially serious side effects, namely, drug-induced bullous pemphigoid
The disorders include SLE, antiphospholipid syndrome (APS), Sjogren's syndrome, systemic sclerosis (SSc), Still's disease, AAV, Behcet's disease, cryoglobulinemia, poly/dermato-myositis, scleroderma, as well as pemphigus vulgaris, bullous pemphigoid
, epidermolysis bullosa, ITP, and thrombotic thrombocytopenic purpura.
A 9-year-old boy presented to the Dermatology Department for the follow-up of a bullous pemphigoid
Examples of autoimmunity diseases include celiac disease, diabetes mellitus type 1, sarcoidosis, systemic lupus erythematosus (SLE), Sj6gren's syndrome, Churg-Strauss syndrome, Hashimoto's thyroiditis, Graves' disease, idiopathic thrombocytopenic purpura, Addison's disease, rheumatoid arthritis (RA), polymyositis (PM), dermatomyositis (DM), pemphigus vulgaris, cicatricial pemphigoid
, multiple sclerosis, inflammatory bowel diseases (e.
Painful oropharyngeal lesions occur in granulomatosis with polyangiitis or Wegener granulomatosis, and autoimmune bullous diseases such as cicatricial pemphigoid
and pemphigus vulgaris.
The Company's lead product candidate, bertilimumab, is entering Phase II clinical studies for moderate to severe ulcerative colitis and bullous pemphigoid
, with additional studies planned for Crohn's disease and severe asthma.
Vicious rare auto-immune skin disease Bullous Pemphigoid
is normally confined to people over 60.
Bertilimumab may be indicated for inflammatory disorders including inflammatory bowel disease (Crohn's Disease and ulcerative colitis), severe asthma, and orphan dermatological conditions such as bullous pemphigoid
Finally, several dermatologic conditions, most notably bullous pemphigoid
and dermatitis herpetiformis, can be associated with blood eosinophilia.
Flageul B, Hassan E Pinquier L, Blanchet-Bardon C, Dubertret L: [Lichen pemphigoid
associated with developing hepatitis B in a child].