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penetrance

   Also found in: Medical, Encyclopedia, Wikipedia 0.01 sec.
pen·e·trance  (pn-trns)
n.
The frequency, under given environmental conditions, with which a specific phenotype is expressed by those individuals with a specific genotype.

penetrance [ˈpɛnɪtrəns]
n
(Life Sciences & Allied Applications / Genetics) Genetics the percentage frequency with which a gene exhibits its effect
[from penetr(ant) + -ance, on the model of German penetranz]


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Prevalence and penetrance of BRCA1 and BRCA2 mutations in a population-based series of breast cancer cases.
Mixed hyperlipidaemias result from accumulation of remnants when apoE is defective (dysbetalipoproteinaemia--usually recessively inherited) or when increases in LDL and VLDL co-exist, such as may be the case in familial combined hyperlipidaemia (usually autosomally dominantly inherited but with variable penetrance of cholesterol or triglyceride elevation in the family).
 
 
 
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