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Any of several beta-lactamase enzymes that cleave the beta-lactam ring in penicillins. Penicillinases are found in many penicillin-resistant bacteria.


(Medicine) any of a group of enzymes used to treat allergic reactions to penicillin
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Noun1.penicillinase - enzyme produced by certain bacteria that inactivates penicillin and results in resistance to that antibiotic
enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions
References in periodicals archive ?
saprophyticus was the exception as the majority of other staphylococci are penicillinase producers (13).
The penicillinase enzyme has been used in the production of the sensor.
incorporating biochemical tests for their identification, including penicillinase production / 2000.
Reductions were found for all classes of antibiotics other than penicillinase resistant penicillins but were largest and significant individually for phenoxymethylpenicillins (penicillin V) (7.
37]Ra in stick penicillinase ELISA for the detection of seroreactivity in pulmonary and extrapulmonary TB, ES-31 showed good potential in detecting IgG antibody in TB Lymphnode, Tubercular meningitis and pulmonary TB.
aureus that produced penicillinase, a [beta]-lacta mase that deactivates penicillin by cleaving a bond in the b-lactam ring.
In the gonococci, the chromosomally mediated expression of multiple resistance genes and the production of the penicillinase plasmid TEM-1 [beta]-lactamase are 2 independent mechanisms involved in a susceptible-to-resistant strain switch.
Penicillin and cephalosporins are not recommended for initial treatment due to the demonstration of a cephalosporinase and an inducible penicillinase in the anthrax genome.
Nafcillin and other drugs in its antibiotic class are particularly useful for the treatment of infections involving penicillinase-producing strains of Staphylococcus aureus, because they are highly resistant to inactivation by the enzyme penicillinase (beta-lactamase).
tetM- and [beta]-lactamase-containing Neisseria gonorrhoeae (tetracycline resistant and penicillinase producing) in the Netherlands.

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