Bacterial cell shape is defined by an exoskeleton-like structure composed of peptidoglycan
A potentially invaluable spin-off from the study is the fact that the scientists have identified every biological step a bacterial cell uses to produce peptidoglycan
Girardin SE, Travassos LH, Herve M, Blanot D, Boneta LG, Philpott DJ, Sansonetti PJ, Mengin-Lecreulx D (2003) Peptidoglycan
molecular requirements allowing detection by Nod1 and Nod2.
Shi and colleagues say the protein and two closely related proteins discovered in the study are similar in genetic sequence to peptidoglycan
, which is known to make and modify chemicals in the cell walls of the microbe.
Tokyo, Japan, June 13, 2006 - (JCN) - Tohoku University's Graduate School of Pharmaceutical Sciences has elucidated the roles of peptidoglycan
recognition protein (PGRP)-LE in natural immunity in collaboration with the University of Massachusetts Medical School.
Particular emphasis is placed on epimerases and racemases, sugar nucleotide-modifying enzymes, and the enzymes of sialic acid and peptidoglycan
When vancomycin works, it inhibits Gram-positive bacterial cell wall assembly by binding to the terminal D-Ala-D-Ala of peptidoglycan
building blocks, a specifically configured chain of amino acids linked by peptide bonds.
MADISON Wisconsin ADONISM (Bloomsbury Thesaurus), AMIDONS (pl of amidon, Web2), ASMONDI (Asmondi, a demon, OED father 1916q), DAIMONS (OSPD), D-AMINOS (pl of damino, OED peptidoglycan
1975q), DAMIONS (Damion's [or plural] OED round-house 1958q), DAMONIS (Damonis = of Damon, OED Latian 1879q), DAMOSIN (OED damson), DIAMONS (= diamonds, OED pointed 1575q), DIMONAS (pl of Dimona, author OED yacht 1974q), DOMAINS (Mathematical Glossary of Exciting, Enervating, Scintillating, and Vibrant Terms [privately published], and many other sources), DOMINAS (pl domina), MAIDONS (OED head 1400q), MANDIOS (pl of mandio, OED manioc), MANIDOS (ST: pl of OED manido = Manitou), MONDIAS (pl of m ondia, a genus of dicotyledon), MONIDAS (pl of Monida, town on Montana-Idaho border), ODISMAN (OED oddsman)
The protein is likely to be an ATP-dependent regulator of peptidoglycan
metabolism given the distribution of conserved residues and structural features typical for "molecular switches".
FROM GROUP B STREPTOCOCCUS AS A TARGET FOR NATURAL 1gM ANTIBODIES IN MICE
Our group's research focuses on the rational drug design of a novel peptidomimetic of the D-Ala-D-Ala peptidoglycan
moiety as a bacterial cell wall synthesis inhibitor.
Gram-negative Refers to special characteristics of the bacterial cell wall -- a highly complex cell wall that is low in peptidoglycan
and high in lipopolysaccharides.