phage display


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phage display

n.
A method of using genetically modified bacteriophages to make new proteins and replicate selected proteins, enabling the engineering of antibodies and the development of new drugs.

[From the fact that the proteins are displayed on the surface of the bacteriophages .]
References in periodicals archive ?
US-based biologics company LakePharma has signed a non-exclusive license agreement with XOMA to use XOMA's 031 Fab Phage Display Library in its antibody discovery service to pharma and therapeutic biotech companies, the company said.
Phage display technology is a widely used method for the selection of peptides (10,11,12).
Phage Display in Biotechnology and Drug Discovery, 2nd Edition
Phage display technique enables the identification of antibody fragments against specific antigens through the screening of huge number of potential binders from a genetic polypeptide library [14].
com)-- The services range from phage display library construction (such as cDNA libraries, peptide libraries and scFv/Fab antibody libraries) to phage display screening (including screening of phage display peptide, cDNA and scFv/Fab libraries).
The agreement involves multiple proprietary XOMA antibody research and development technologies, including a new XOMA phage display library, and a suite of integrated information and data management systems.
Since its introduction about 20 years ago, phage display technology has revolutionized the analysis of biomedical problems and clinical applications in the fields of immunology, cell biology, biotechnology, pharmacology and drug discovery.
Universite Pierre et Marie Curie (ParisVI) (Paris Cedex, France) and Universite De Geneve (Geneva, Switzerland) have patented a method for the design and/or the selection of agonist or antagonist chemokine variants combining a phage display technology and a screening on living cells expressing the receptor of the corresponding native chemokine.
USDA-ARS microbiologists and chemists have employed phage display to isolate an antibody fragment that binds specifically to L.
Brewster have used phage display to isolate an antibody fragment that binds specifically to L.
Content covers such topics as differential display, electrophoresis, genotyping, transgenic systems, mutation screens, protein spectrometry, comparative genomics and phage display.
Although the peptides and antibodies identified through phage display in these examples are useful in diagnostic assays, landscape phage probes may be better suited for the exacting requirements of environmental monitoring, in which robust, selective, strong, and inexpensive binders capable of operating in severe environmental conditions are needed.